医院近10年肾活检成年患者性别、年龄及疾病谱变化研究  

Demographic and clinicopathological profile of kidney biopsy in Lihuili Hospital last decade

作　　者：蔡莹 杨金国[1] 吴迪英[1] 郭蓓[1] 许红 蒋晓立 陈生[1] CAI Ying,YANG Jinguo,WU Diying,et al.(Department of Nephrology,Ningbo Medical Center,Lihuili Hospital,Ningbo 315040,China)

机构地区：[1]宁波市医疗中心李惠利医院肾内科,315040

出　　处：《浙江医学》2018年第19期2133-2137,共5页Zhejiang Medical Journal

摘　　要：目的分析医院近10年肾活检成年患者性别、年龄及疾病谱变化。方法回顾性研究宁波市医疗中心李惠利医院近10年(2008至2017年)1 158例肾活检成年患者性别、年龄及疾病谱变化,其中前5年(2008至2012年)401例,后5年(2013至2017年)757例,并作统计分析。结果后5年患者年龄明显大于前5年(P<0.05)。医院近10年最常见的肾脏疾病为原发性肾脏病(PGD)占82.0%,其次为继发性肾脏病(SGD)占13.7%,肾小管间质病(TID)占1.5%,遗传性肾脏病(HN)占0.8%。后5年PGD的比例明显下降(P<0.05),而SGD的比例明显上升(P<0.05)。在PGD及SGD患者中,男性患者的年龄明显高于女性患者(均P<0.05),而在HN患者中,女性患者的年龄明显高于男性(P<0.05)。PGD中,IgA肾病(IgAN)最常见,占51.5%,其次为膜性肾病(MN)占25.6%。后5年MN、微小病变肾病(MCD)及局灶节段硬化性肾小球肾炎(FSGS)的比例明显上升(P<0.05),而肾小球轻微病变(GML)、IgAN及系膜增生性肾小球肾炎(Ms PGN)的比例明显下降(P<0.05)。SGD中,最常见的狼疮性肾炎(LN)占33.3%,紫癜性肾炎(HSN)占22.6%,糖尿病肾病(DN)占16.4%。后5年LN的比例明显下降(P<0.05),而DN的比例明显上升(P<0.05)。结论 PGD是成人肾活检中最主要的病理类型,而IgAN又为PGD中最常见类型,近年来SGD的比例有上升趋势。Objective To review the demographic and clinicopathological profile of adult kidney biopsies in LihuiliHospital last decade. Methods The demographic and clinicopathological profile of 1158 adult renal biopsies performed inLihuili Hospital from 2008 to 2017 were retrospective analyzed. There were 401 cases performed in the first 5-year（2008-2012） and 757 cases performed in last 5-year （2013-2017）. Results The age of the patients in last 5 years wassignificantly greater than that in the first 5 years（P〈0.05）. The most common type of renal diseases was primary glomerulardisease （PGD） （82.0%）, followed by secondary glomerular disease （SGD） （13.7%）, tubular interstitial disease （TID） （1.5%） andhereditary kidney diseases （HN） （0.8%）. The proportion of PGD had dropped remarkably in last five years（P〈0.05） and that ofSGD was increased greatly（P〈0.05）. In PGD and SGD patients, the age of male patients was significantly higher than that offemale patients （all P〈0.05）, while in HN patients, the age of female patients was significantly higher than that of male patients（P〈0.05）. In PGD, IgA nephropathy （IgAN） was the most common one （51.5%）, followed by membranous nephropathy （MN）（25.6%）. The proportion of MN, minimal change disease （MCD） and focal segmental glomerulosclerosis （FSGS） increasedsignificantly（P〈0.05）, and that of glomerular minor lesion （GML）, IgAN and mesangial proliferative glomerulonephritis （MsPGN）decreased significantly（P〈0.05）. Lupus nephritis （LN）, the most common type of SGD, accounted for 33.3%, Henoch-Schonleinnephritis （HSN） accounted for 22.6%, and diabetic nephropathy （DN） accounted for 16.4% of all SGD cases. The proportion of LNdropped significantly（P〈0.05）, in contrast that of DN increased（P〈0.05）. Conclusion PGD is the most important pathologicaltype in adult renal biopsy, and IgAN is the most common type in PGD. In recent years, the proportion of SGD has incr

关 键 词：肾脏疾病 病理 回顾性研究 肾活检 

分 类 号：R692[医药卫生—泌尿科学]