孕酮和β亚单位人绒毛膜促性腺激素对早期先兆流产保胎结局影响的临床研究  

The effect of progesterone value and beta subunit human chorionic gonadotrophin on the outcome of early warning abortion

作　　者：王金波[1] 孙敏[1] WANG Jin-bo;SUN Min(Department of Clinical Laboratory,Baoji People＇s Hospital,Baoji Shaanxi 721000,China.)

机构地区：[1]陕西省宝鸡市人民医院检验科,陕西宝鸡721000

出　　处：《临床和实验医学杂志》2018年第19期2115-2118,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探究孕酮、β亚单位人绒毛膜促性腺激素(β-HCG)对早期先兆流产保胎结局的影响。方法回顾性分析陕西省宝鸡市人民医院2016年2月至2017年2月收治的170例早期先兆流产患者经保胎治疗的临床资料,根据治疗结果分为治疗成功组82例和治疗失败组88例,对比两组停经12周时的血清孕酮、β-HCG水平。分析早期先兆流产保胎治疗结局的影响因素,两组治疗后血清孕酮、β-HCG阳性率以及血清孕酮和β-HCG联合检测对妊娠结局的预测价值。结果于停经第12周时,治疗成功组的血清孕酮和β-HCG均高于治疗失败组(P<0.05)。经二分类Logistic回归分析显示,血清孕酮和β-HCG阳性是早期先兆流产保胎结局的保护因素。保胎治疗成功组的血清孕酮、β-HCG阳性率均高于治疗失败组(P<0.05)。血清孕酮和β-HCG联合检测在对妊娠结局预测中,其特异度、敏感度和准确率分别为95.33%、82.63%、88.24%,假阳性预测值和假阴性预测值分别为4.27%、17.37%。结论血清孕酮和β-HCG联合检测可作为预测早期先兆流产患者保胎结局的重要指标,且特异度、敏感度和准确率均较高,进而对预测保胎治疗结果有重要价值。Objective To explore the effect of progesterone and, β-human chorionic gonadotropin （β-HCG） on the outcome of early premonitory abortion. Methods The clinical data of 170 patients with early threatened abortion in this hospital during February 2016 to February 2017 after miscarriage treatment, according to treatment were divided into treatment group of 82 cases and treatment failure group 88 cases, compared two groups of the menopause at 12 weeks had been compared , serum progesterone level of 3 -HCG. Analysis of the factors affecting the outcome of treatment for early threatened abortion, two groups after treatment, the positive rate of serum progesterone and progesterone beta -HCG and beta -HCG combined detection of the predictive value of pregnancy outcome. Results At twelfth weeks of menopause, the serum levels of progesterone and beta -HCG in patients of treatment group were higher than those in treatment failure group （ P 〈0.05）. The two classification Logistic regression analysis showed that serum levels of progesterone and positive beta -HCG positive beta is a protective factor for Early Threatened Abortion outcome. Serum progesterone, beta -HCG positive rate of miscarriage treatment success group were higher than those of treatment failure group （ P 〈0.05）. The specificity, sensitivity and accuracy of combined detection of serum progesterone and beta -HCG in prediction of pregnancy outcome were 95.33%, 82.63% and 88.24%, respectively, and the false positive predictive value and false negative predictive value were 4.27% and 17.37% respectively. Conclusion The combined detection of serum levels of progesterone and beta -HCG can be used as an important index to predict the outcome of patients with early threatened abortion miscarriage, and the specificity, sensitivity and accuracy are high, and the prediction results have important value of tocolytic therapy.

关 键 词：早期先兆流产 孕酮 β 亚单位人绒毛膜促性腺激素 保胎结局 

分 类 号：R714.21[医药卫生—妇产科学]