手性香料的不对称催化合成研究进展  

Progress on the Asymmetric Catalytic Synthesis of Chiral Flavors and Fragrances

作　　者：樊超 谢建华[1] 周其林[1] FAN Chao;XIE Jianhua;ZHOU Qilin(State Key Laboratory and Institute of Elemento-organic Chemistry,Nankai University,Tianjin 300071,China)

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《应用技术学报》2018年第3期189-219,共31页Journal of Technology

基　　金：国家自然科学基金项目(21790330;21532003;21421062)资助

摘　　要：手性香料已在化妆品、食品和医药等中得到了广泛的应用。由于人的嗅觉和味觉受体是由手性分子构成,不同对映异构体香料其香气存在差异。因此,为了避免手性香料"无效"异构体带来的潜在风险,以及降低香料的使用量,减少废物排放和保护环境,发展手性香料高效异构体的不对称合成方法显得尤为重要。随着不对称催化合成技术发展,其在手性香料高效异构体的合成上也得到了越来越多的应用。本文以L-薄荷醇、二氢茉莉酮酸甲酯、麝香酮、玫瑰醚等手性香料为例介绍手性香料的不对称催化合成研究进展。Chiral flavors and fragrances have been widely used in cosmetics, food, medicine, etc. Because human olfactory and taste receptors are made up of chiral biomolecules, the aromas of different enantiomers of chiral flavors and fragrances are not the same. Therefore, in order to avoid the potential risks caused by the “ineffective” enantiomers of chiral flavors and fragrances, reduce the use and discharge of wastes, and protect the environment, it is particularly important to develop efficient methods for the asymmetric synthesis of chiral flavors and fragrances. Great progress has been achieved in the field of catalytic asymmetric catalysis in last decades. A number of catalytic asymmetric reactions have been applied to the synthesis and productions of enantiomeric pure chiral flavors and fragrances. In this paper, we briefly review the progress on the study of catalytic asymmetric synthesis of chiral flavors and fragrances including L -methanol, methyl dihydrojasmonate, muscone, rose oxide, etc.

关 键 词：手性香料 不对称催化 L-薄荷醇 二氢茉莉酮酸甲酯 麝香酮 

分 类 号：TQ651[化学工程—精细化工]