硫巯基化:一种新的蛋白质翻译后修饰  

S-sulfhydration: A New Post-Translational Modification of Proteins

作　　者：梅玉东 金欣欣 黄丽琴[2] MEI Yu-Dong;JIN Xin-Xin;HUANG Li-Qin(College of Life Sciences,Nanjing Agricultural University,Nanjing 210095,China;College of Sciences,Nanfing Agricultural University,Nanjing 210095,China)

机构地区：[1]南京农业大学生命科学学院,南京210095 [2]南京农业大学理学院,南京210095

出　　处：《中国生物化学与分子生物学报》2018年第9期911-920,共10页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31772292)~~

摘　　要：随着对硫化氢(hydrogen sulfide,H_2S)生理效应的研究,蛋白质硫巯基化(S-sulfhydration)修饰已进入人们的视野。已知依赖于H_2S的蛋白质硫巯基化是继磷酸化(phosphorylation)、泛素化(ubiquitylation)、乙酰化(acetylation)和S-亚硝基化(S-nitrosylation)等之后的一种新的蛋白质翻译后修饰方式。对动物的研究表明,蛋白质硫巯基化修饰通过影响蛋白质活性和功能,从而在细胞内信号通路中发挥重要的调控作用。最近的研究结果提示,硫巯基化修饰还参与调节植物新陈代谢和形态建成。本文阐述了依赖于H_2S的蛋白质硫巯基化的作用机制、检测方法和生理功能,并提出硫巯基化修饰也可能参与植物细胞信号转导的观点。With the advances in research on physiological functions of H2S,protein S-sulfhydration has emerged as a new mechanism for H2S to exert its effects. Similar to phosphorylation,ubiquitylation,acetylation and S-nitrosylation, H2S-dependent S-sulfhydration is another new post-translational modification. Research in animals revealed that protein S-sulfhydration plays significant roles in the regulation of intracellular signaling pathways through the modification of protein activity and function.Recently,research in plants implied that S-sulfhydration was involved in the regulation of plant metabolism and morphogenesis. This review focuses on mechanisms,detection methods,biological and physiological functions of H2S-dependent S-sulfhydration. Finally,we propose that S-sulfhydration may be involved in cell signaling transduction pathways in plants.

关 键 词：硫巯基化 硫化氢 作用机制 检测方法 生理功能 

分 类 号：Q5[生物学—生物化学] Q7