小剂量糖皮质激素治疗老年原发性肾病综合征的疗效和安全性研究  

Research on efficacy and safety of low dose glucocorticoid in the treatment of elderly patients with primary nephrotic syndrome

作　　者：戴晖 刘谓[2] DAI Hui;LIU Wei(Department of Nephrology,Xinjiang Production and Construction Corps 13 Division Red Star Hospital,Hami 839000,China)

机构地区：[1]新疆生产建设兵团第十三师红星医院肾内科,839000 [2]河南省人民医院肾病风湿免疫科,450003

出　　处：《中国实用医药》2018年第25期98-99,共2页China Practical Medicine

基　　金：河南省医学科技攻关计划项目(项目编号:2011020132)

摘　　要：目的探讨小剂量糖皮质激素治疗老年原发性肾病综合征患者的临床疗效和安全性。方法 43例老年肾病综合征患者,随机分为观察组(23例)和对照组(20例)。两组患者均应用常规治疗,观察组应用小剂量糖皮质激素治疗,对照组未应用糖皮质激素治疗。观察并比较两组临床疗效和不良反应发生情况。结果观察组患者总有效率为65.22%,高于对照组的35.00%,差异有统计学意义(χ~2=3.909,P=0.048<0.05)。两组患者不良反应发生率比较,差异无统计学意义(χ~2=0.010,P=0.920>0.05)。结论小剂量糖皮质激素治疗老年肾病综合征患者所获效果优于未应用激素治疗的患者。Objective To investigate the clinical efficacy and safety of low dose glucocorticoid in the treatment of elderly patients with primary nephrotic syndrome. Methods A total of 43 elderly patients with nephrotic syndrome were randomly divided into observation group for 23 cases and control group for 20 cases. Patients of the two groups were treated with conventional therapy, the observation group was treated with low dose of glucocorticoid, the control group was not treated with glucocorticoid. The clinical efficacy and adverse reactions between the two groups were observed and compared. Results The total effective rate of the observation group was 65.22%, which was significantly higher than 35.00% of the control group, the difference was statistically significant （X2=3.909, P=0.048〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups.（X2=O.010, P=0.920〉0.05）. Conclusion The treatment effect of low dose glucocorticoid for elderly patients with nephrotic syndrome is better than patients without hormone therapy.

关 键 词：肾病综合征 老年 糖皮质激素 

分 类 号：R692[医药卫生—泌尿科学]