早期应用单唾液酸四己糖神经节苷脂对急性期颅脑损伤治疗的价值分析  

Value analysis of early application of Monosialotetrahexosylganglioside in the treatment of acute craniocerebral injury

作　　者：张剑平[1] 李亦明[1] 杨祝文 ZHANG Jian-ping;LI Yi-ming;YANG Zhu-wen(Department of Neurosurgery,The People＇s Hospital of Wuhua County,Wuhua 514400,China)

机构地区：[1]五华县人民医院神经外科,514400

出　　处：《中国实用医药》2018年第25期131-132,共2页China Practical Medicine

摘　　要：目的探讨早期应用单唾液酸四己糖神经节苷脂(GM1)对急性期颅脑损伤治疗的价值。方法 120例急性期颅脑损伤患者,通过电脑完全随机分组法分为常规组与研究组,各60例。常规组应用常规对症支持治疗,研究组在常规组基础上早期应用单唾液酸四己糖神经节苷脂治疗。比较两组患者的疗效及治疗前后格拉斯哥昏迷量表(GCS)评分。结果研究组总有效率为96.67%,显著高于常规组的83.33%,差异有统计学意义(P<0.05)。治疗前,两组患者GCS评分比较,差异无统计学意义(P>0.05);治疗后,两组患者GCS评分高于治疗前,且研究组患者GCS评分高于常规组,差异具有统计学意义(P<0.05)。结论急性期颅脑损伤患者早期应用单唾液酸四己糖神经节苷脂的治疗价值较高,有利于改善患者预后,值得临床进一步应用。Objective To investigate the value of early application of Monosialotetrahexosylganglioside in the treatment of acute craniocerebral injury. Methods A total of 120 patients with acute craniocerebral injury were divided into conventional group and research group by computer completely random grouping method, 60 cases in each group. The conventional group was given conventional symptomatic support treatment, the research group was given early application of Monosialotetrahexosylganglioside treatment on the basis of conventional group. The efficacy and the Glasgow coma scale （GCS） score between the two groups before and after treatment were compared. Results The total effective rate of the research group was 96.67%, which was significantly higher than 83.33% of the conventional group, the difference was statistically significant （P〈0.05）. Before treatment, there was no significant difference in the GCS score between the two groups （P〉0.05）. After treatment, the GCS score of the two groups were significantly higher than those before treatment, and the GCS score of the research group was significantly higher than that of the conventional group, the difference was statistically significant （P〈0.05）. Conclusion The value of early application of Monosialotetrahexosylganglioside in the treatment of acute craniocerebral injury is high, which is conducive to improving the prognosis of patients and worthy of further clinical application.

关 键 词：急性期颅脑损伤 单唾液酸四己糖神经节苷脂 价值 

分 类 号：R651.15[医药卫生—外科学]