Applications of CBT-Cys click reaction: past, present, and future  

作　　者：Miaomiao Zhang Gaolin Liang 

机构地区：[1]Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China

出　　处：《Science China Chemistry》2018年第9期1088-1098,共11页中国科学（化学英文版）

基　　金：supported by the Ministry of Science and Technology of China (2016YFA0400904);the National Natural Science Foundation of China (21725505, 21675145);the Major program of Development Foundation of Hefei Center for Physical Science and Technology (2016FXZY006)

摘　　要：Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole(CBT) and D-cysteine(D-Cys) in fireflies and has high biocompatibility and controllability in physiological solutions. Under the control of p H, reduction, or enzyme, this CBTbased click reaction has been widely applied to a wide range of biomedical fields such as protein labeling, molecular imaging(e.g., optical imaging, nuclear imaging, magnetic resonance imaging and photoacoustic imaging), nanomaterial fabrication, cancer therapy, and other potentialities.Herein, we review the development, applications and potential prospects of CBT-Cys click reaction. This click condensation reaction is based on the condensation reaction between 2-cyanobenzothiazole（CBT） and D-cysteine（D-Cys） in fireflies and has high biocompatibility and controllability in physiological solutions. Under the control of p H, reduction, or enzyme, this CBTbased click reaction has been widely applied to a wide range of biomedical fields such as protein labeling, molecular imaging（e.g., optical imaging, nuclear imaging, magnetic resonance imaging and photoacoustic imaging）, nanomaterial fabrication, cancer therapy, and other potentialities.

关 键 词：CBT-Cys click reaction SELF-ASSEMBLY DISASSEMBLY molecular imaging cancer therapy 

分 类 号：O621.25[理学—有机化学]