基于功能近红外光谱技术的镜像运动脑激活特征的初步研究  

Brain activation characteristics during mirror movements in healthy subjects:findings by functional near-infrared spectroscopy

作　　者：张静娜[1] 王莉[1] 张晔[1] 杨昆 桑林琼[1] 李鹏岳[1] 邱明国[1] ZHANG Jingna;WANG Li;ZHANG Ye;YANG Kun;SANG Linqiong;LI Pengyue;QIU Minguo(Department of Medical Imaging,Faculty of Biomedical Engineering,Army Medical University（Third Military Medical University）,Chongqing,400038,China)

机构地区：[1]陆军军医大学(第三军医大学)生物医学工程系医学图像学教研室,重庆400038

出　　处：《第三军医大学学报》2018年第18期1682-1687,共6页Journal of Third Military Medical University

基　　金：国家自然科学基金青年科学基金(81601970);第三军医大学第一附属医院转化医学合作课题(SWH2014ZH03);第三军医大学青年培育项目(2016XPY05;2017XQN04)~~

摘　　要：目的研究在镜像运动任务时大脑功能激活特征,为镜像运动疗法治疗截肢后幻肢痛提供脑功能影像学依据。方法招募13名健康被试,被试者均为本校的在校师生,采用功能性近红外光谱技术检测被试在左足运动执行和右足镜像运动时其大脑感觉运动皮层激活情况,以及大脑皮层含氧血红蛋白(Hb O2)相对浓度变化时程特点。结果右足镜像运动与左足运动执行时,均显著激活双侧大脑主运动区和初级感觉皮层,其中激活最强的脑区在大脑右侧的初级感觉运动皮层(P<0.05)。镜像任务Hb O2相对浓度时间变化曲线出现下降趋势的时间早于运动执行,但两种任务Hb O2浓度变化均值差异无统计学意义(P>0.05)。结论功能近红外光谱技术研究结果证实了镜像运动和运动执行具有相似大脑激活模式和激活强度。Objective To study the brain activation characteristics during mirror movements and provide functional near-infrared spectroscopy（f NIRS） evidence to support mirror therapy for phantom limb pain after amputation. Methods Thirteen healthy subjects（including 10 male and 3 female subjects,aged22 ~ 34 years） were recruited in this study. f NIRS was used to measure brain activation and the changes in the relative concentration of oxygenated hemoglobin（Hb O2） in the sensorimotor cortex during the execution of movements of the left foot and mirror movements of the right foot. Results Both of the two tasks activated the bilateral primary motor cortex and the primary sensory cortex,and the right primary sensorimotor cortex showed the strongest activation（P 0. 05）. The mean Hb O2 concentration during the execution of the two tasks showed no significant difference,but a downward trend occurred in the time course of Hb O2 concentration changes in the mirror movements before the execution of movements（P 0. 05）. Conclusion Our findings confirm that the brain activation patterns and intensity are similar during the execution of movements of the left foot and mirror movements of the right foot,which supports mirror therapy for treatment of phantom limb pain after amputation.

关 键 词：功能近红外光谱技术 镜像运动 脑激活模式 神经机制 

分 类 号：R338.2[医药卫生—人体生理学] R446.9[医药卫生—基础医学]