免疫治疗或可实现慢性乙型肝炎的功能性治愈  

Immunotherapy may improve functional cure of chronic hepatitis B

作　　者：祝丹 潘雯 刘嘉[1] 杨东亮[1] Zhu Dan;Pan Wen;Liu Jia;Yang Dongliang(Department of Infectious Diseases,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院感染病科,武汉430022

出　　处：《中华临床感染病杂志》2018年第4期261-268,共8页Chinese Journal of Clinical Infectious Diseases

基　　金：国家自然科学基金资助项目（81461130019,91642118,91742114）;国家科技重大专项资助项目（2012ZX10004503,2013ZX10002001-001-006,2017ZX10202202,2017ZX10202201,2017ZX10202203）;华中科技大学同济医学院重大疾病交叉新团队资助项目（500153003）

摘　　要：临床现有的针对慢性HBV感染的抗病毒治疗手段可以有效地控制HBV复制，但在绝大多数患者中仍难以实现HBsAg的清除和安全停药，即慢性乙型肝炎（CHB）的功能性治愈。机体的免疫应答在HBV的清除中起着关键作用，通过激活患者的天然免疫和适应性免疫应答有望实现对HBV感染的持续控制，从而显著提高CHB的功能性治愈率。本文对近年来CHB功能性治愈相关的免疫学研究进展进行总结。Currently, clinical antiviral therapies for chronic hepatitis B virus （HBV） infection can efficiently control HBV replication. However, it remains difficult to achieve HBsAg clearance and sustains off-therapy, that is the functional cure of chronic hepatitis B （CHB） in most of patients. Host immune responses play critical roles in HBV clearance and HBV infection control by activating innate and adaptive immune responses, resulting in improving the functional cure rate of patients with CHB. This article reviews the recent advances in immunology studies related to functional cure of CHB.

关 键 词：肝炎 乙型 慢性 免疫 先天 免疫 体液 适应性免疫 功能性治愈 

分 类 号：R512.62[医药卫生—内科学]