Hf(OTf)_4催化Biginelli反应合成3,4-二氢嘧啶-2(1H)-酮  

Synthesis of DHPMs by Biginelli Reaction with Hf(OTf)_4 as Catalyst

作　　者：丁亚军 余晨蓓 陈沛然[1] Ding Ya-jun;Yu Chen-bei;Chen Pei-ran(College of Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620;Shanghai No.2 Middle School,Shanghai 200031)

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]上海市第二中学,上海200031

出　　处：《生物化工》2018年第3期21-25,共5页Biological Chemical Engineering

基　　金：国家自然科学基金资助项目(21272305)

摘　　要：以含有不同取代基的芳香醛、脲(尿素、硫脲)、乙酰乙酸乙酯为反应原料,以Hf(OTf)_4为催化剂,采取"一锅煮"的方式,利用Biginelli反应合成一系列含O-和S-DHPMs化合物。By using Hf（OTf）4 as catalyst, a series of 2-selenoxo DHPMs have been synthesized efficiently in good yields by Biginelli reaction with aromatic aldehyde, urea（urea, thiourea）, ethyl acetoacetate as starting material.

关 键 词：Hf(OTf)4 BIGINELLI反应 DHPMs 多组分反应 

分 类 号：TQ251[化学工程—有机化工]