五子衍宗方与左卡尼汀治疗男性不育症的Meta分析  被引量:2

Meta-analysis of wuziyanzong and levocarnitine for male infertility

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作  者:何芳香 毛雄伟[2] 吴慧[2] He Fangxiang;Mao Xiongwei;Wu Hui(Department of Traditional Chinese Medicine,Jiangshan People's Hospital,Quzhou 324100,China)

机构地区:[1]江山市人民医院药剂科,1324100 [2]江山市人民医院中医科

出  处:《中国医院统计》2018年第4期245-249,共5页Chinese Journal of Hospital Statistics

摘  要:目的评价五子衍宗方与左卡尼汀治疗男性不育症的临床疗效。方法检索五子衍宗方治疗男性不育症的临床随机对照研究(RCTs),根据Cochrane 5.1手册要求,分别选择研究、提取数据并评价纳入RCTs的质量,使用RevMan 5.3软件进行Meta分析。结果纳入4项研究,共324例患者。Meta分析显示,五子衍宗方有效率(RR=1.25,95%CI:0.99~1.58,P=0.06)、受孕率(RR=1.76,95%CI:0.81~3.82,P=0.15)、精液量增加值(MD=-0.04,95%CI:-0.41~0.34,P=0.85)、精子密度增加值(SMD=0.65,95%CI:-0.12~1.43,P=0.10)、A级精子百分率提高值(MD=1.89,95%CI:-10.41~14.20,P=0.76)、A+B级精子百分率提高值(MD=3.42,95%CI:-5.00~11.84,P=0.43)均与左卡尼汀相当,但精子活率提高值不及左卡尼汀(MD=-12.42,95%CI:-22.06^-2.78,P=0.01)。结论本次系统评价结果显示,五子衍宗方治疗男性不育症疗效有一定的价值,但鉴于纳入研究有一定的局限性,需按中医辩证论治来设计良好的大规模临床随机对照研究来验证。Objective To systematically evaluate the efficacy of wuziyanzong and levocarnitine in the treatment of male infertility. Methods Based on the principles and methods of Cochrane systematic reviews,we searched Pub Med,Embase,the Cochrane Library,EBSCO,CNKI,VIP,CBM and Wanfang databases from inception to July 2017 for randomized controlled clinical trials addressing the treatment of male infertility with wuziyanzong. According to the inclusion and exclusion criteria and retrieval strategies,we extracted the data,evaluated the quality of the included literature,and conducted meta-analysis using the Rev Man 5.3 software. Results Four trials involving 324 patients were included. The results of meta-analysis showed that effectiveness rate (RR = 1.25,95% CI:0. 99 - 1. 58,P = 0. 06),confirmed pregnancy rate (RR = 1. 76,95% CI:0. 81 - 3. 82,P = 0. 15),△semen volume(MD=-0.04,95%CI:-0.41-0.34,P= 0.85),△sperm density(SMD= 0.65,95%CI:-0.12- 1. 43,P = 0.10),△grade A sperm rate(MD= 1.89,95%CI:-10.41-14.20,P= 0.76)and △grade A+B sperm rate(MD = 3. 42,95%CI:-5.00-11.84,P = 0. 43) of wuziyanzong group were not inferior to those of levocarnitine group,but △sperm motility of wuziyanzong group was inferior to that of levocarnitine group (MD =-12.42,95%CI:-22.06 --2.78,P = 0.01). Conclusion According to this evaluation system,wuziyanzong treatment of male infertility has some curative effect,but because of some limitations,it still needs large-scale randomized controlled clinical trial for verification according to dialectics of traditional Chinese medicine.

关 键 词:五子衍宗方 左卡尼汀 男性不育症 少弱精子症 META分析 

分 类 号:R698.2[医药卫生—泌尿科学]

 

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