机构地区:[1]广州医科大学附属第一医院微创外科中心泌尿外科广东省泌尿外科重点实验室,广州510230
出 处:《中华泌尿外科杂志》2018年第9期651-655,共5页Chinese Journal of Urology
基 金:国家自然科学基金(81570633);广东省科技计划项目(2017B030314108)
摘 要:目的探讨泌尿系结石患者的结石成分特点及不同年份的变化情况。方法回顾性分析本中心2011年1月至2017年5月收治的15269例泌尿系结石患者的病例资料,男9019例,女6250例。将患者按年龄分为A组(≤18岁)、B组(19-40岁)、C组(41-60岁)、D组(〉60岁)。分析不同性别、年龄、年份患者的结石成分特点。结果结石成分分析结果显示,草酸钙9803例(64.2%),碳酸磷灰石2358例(15.4%),尿酸2125例(13.9%),磷酸钙420例(2.8%),磷酸镁铵395例(2.6%),胱氨酸96例(0.6%),尿酸铵62例(0.4%),其他10例(0.1%)。男性患者的草酸钙结石比例[6221例(69.0%)]高于女性患者[3582例(57.3%)](P〈0.001),而女性患者的磷酸钙[210例(3.4%)]、磷酸镁铵[230例(3.7%)]、碳酸磷灰石(1328例(21.3%)]结石比例均高于男性患者[210例(2.3%)、165例(1.8%)、1030例(11.4%)](P〈0.001)。D组的尿酸结石[679例(20.7%)]比例高于A组[23例(9.1%)]、B组[260例(7.9%)和C组[1163例(13.8%)](P〈0.001)。B组碳酸磷灰石的比例[652例(19.7%)]最高(P〈0.001)。A组的尿酸铵[9例(3.5%)]、胱氨酸[36例(14.2%)]结石的比例最高(P〈0.001)。成年患者中,尿酸结石比例随年龄增长而增加,分别为B组260例(7.9%)、C组1163例(13.8%)、D组679例(20.7%)(P〈0.001);碳酸磷灰石结石比例随年龄增长而减小,分别为B组652例(19.7%)、c组1270例(15.1%)、D组416例(12.7%)(P〈0.001)。随年份增长,草酸钙(OR=0.944,95%C10.927-0.962,P〈0.001)、尿酸铵(OR=0.854,95%C10.742-0.982,P=0.027)结石比例下降,磷酸钙(OR=1.192,95%CI1.127-1.261,P〈0.001)、尿酸(OR:1.042,95%CI1.015-1.069,P=0.Objective To investigate the distribution characteristics and changing tendency of urinary tract stones. Methods From January 2011 to May 2017, clinical data of 15 269 patients treated in our center was retrospectively reviewed. The stone components were detected by the automatic stone infrared spectroscopy system and the predominant components were recorded. There were 9 019 male patients and 6 250 female patients. The patients were divided into four groups according to their age, including group A≤18 years;group B 19 -40 years;group C 41 -60 years;and group D 〉 60 years. Compared the distribution characteristics of urinary tract stones of patient in different groups of sex, age and calendar year. Results Calcium oxalate stones were more prevalent in males than females [6 221 (69.0%)vs. 3 582(57.3% ) ,P 〈0. 001], but calcium phosphate stones [ 210 ( 3.4% ) vs. 210 ( 2.3% ) ], magnesium ammonium phosphate stones [ 230(3.7% ) vs. 165 ( 1.8% ) ] and carbonate apatite stones [ 1 328 (21.3%) vs. 1 030 ( 11.4% ) ] were more common in females than males (P 〈 0. 001, respectively). The proportion of uric acid stones in group D [679(20.7% ) ] was higher than that in group A [23(9.1% )] ,group B[260(7.9% ) ] ,group C [ 1 163( 13.8% )] (P 〈0. 001 ,respectively). The peak of carbonate apatite stones was showed in group B [ 652( 19.7% ) ] (P 〈 0. 001,respectively). Ammonium urate stones [9 (3.5%) ] and cystine stones [ 36 (14.2%) ] were more frequent in group A(P 〈0. 001 ,respectively). In adults,the percentage of uric acid stones increased with age, such as group B [ 260 (7.9%) ], group C [ 1 163 ( 13.8% ) 1, group D [ 679 (20. 7% )]. And the carbonated apatite stones decreased with age, such as group B [652 (19.7%)1, group C [ 1 270 ( 15.1% ) ], group D [ 416 ( 12.7 % ) ] ( P 〈 0. 001, respectively ). Further analysis showed the proportion of calcium oxalate ( OR = 0. 944,95 % C10. 927 - 0. 962, P 〈 0
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