生/制/发酵何首乌化学成分、药理作用及肝毒性研究进展  

Research Progress on Chemical Constituents,Pharmacology and Hepatoxicity of Raw,Processed and Fermented Polygonum multiflorum Thunb

作　　者：林艳[1,2] 肖榕 李春[3] 夏伯候 吴萍[1,2] 林丽美[1,2] 廖端芳 LIN Yan;XIAO Rong;LI Chun;XIA Bohou;WU Ping;LIN Limei;LIAO Duanfang(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208 Hunan,China;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province,Changsha 410208 Hunan,China;Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700 Beijing,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]湘产大宗药材品质评价湖南省重点实验室,湖南长沙410208 [3]中国中医科学院中药研究所,北京100700

出　　处：《中药新药与临床药理》2018年第5期661-672,共12页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金青年基金项目(81503238);国家中医药管理局中医药行业科研专项(201407003);湖南省"十二五"重点学科药学学科资助项目(湘教发[2011]76号);长沙市科技计划重点项目(k1406030-31);湖南省教育厅一般项目(17C1213)

摘　　要：何首乌为蓼科植物何首乌Polygonum multiflorum Thunb.的干燥块根。何首乌含有蒽醌类、二苯乙烯苷类、黄酮类、磷脂类等多种类型的活性成分,具有抗衰老、增强免疫功能、降血脂、补血、抗动脉粥样硬化、抗菌等多方面的药理作用。何首乌肝毒性的临床案例报道日渐增多,其安全性备受关注。通过对生/制/发酵何首乌的化学成分、药理作用及肝毒性进行系统综述,为何首乌深度开发利用提供参考。Polygoni multiflori radix is the root of Polygonum multiflorum Thunb.of Polygonaceae.There are many active chemical constituents in P.multiflorum,such as quinines,stilbenes,flavones,and phosphor lipids.P.multiflorum has many biological activities,includes anti-aging,hypolipidemic and anti-atherosclerosis effects.However,an increasing number of recently published studies have demonstrated the hepatoxicity of P.multiflorum,which draws attention of public.In this review,we provide a systematic comparison between P.multiflorum and related processed products in chemical constituents,pharmacology and hepatoxicity.It can be helpful for the further development and utilization of P.multiflorum.

关 键 词：生何首乌 制何首乌 发酵何首乌 化学成分 药理作用 肝毒性 

分 类 号：R284[医药卫生—中药学] R285.5[医药卫生—中医学]