降压治疗对健康相关生活质量的影响:中国高血压综合防治研究亚组分析  

Impact of Two Antihypertensive Therapy Regimens on Health-related Quality of Life in Hypertensive Patients: Subgroup Analyses of Chinese Hypertension Intervention Efficacy Study

作　　者：蒋雪丽[1] 王月波 谷鸿秋[1] 马丽媛[1] 李卫[1] 王文[1] 张宇清[1] JIANG Xue-li;WANG Yue-bo;GU Hong-qiu;MA Li-yuan;Ll Wei;WANG Wen;ZHANG Yu-qing(State Key Laboratory of Cardiovascular Diseases,National Center for Cardiovascular Diseases and Fuwai Hospital,CAMS and PUMC,Beijing（100037）,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院心血管疾病国家重点实验室,北京市100037

出　　处：《中国循环杂志》2018年第9期842-845,共4页Chinese Circulation Journal

基　　金：国家"十一.五"科技支撑计划课题(2006BAI01A03)

摘　　要：目的:探究以氨氯地平为基础的两种联合降压方案对高血压患者健康相关生活质量(HRQo L)的影响。方法:本研究为中国高血压综合防治研究(CHIEF)亚组分析,使用Euro Qo L五维问卷(EQ-5D)比较(氨氯地平+复方阿米洛利)和(氨氯地平+替米沙坦)两个降压治疗组患者的HRQo L。EQ-5D主要由EQ-5D描述系统和EQ视觉模拟评分(EQ VAS)组成。结果:在13 542例受试者中,13 499例(99.7%)符合试验条件。与基线水平相比,所有受试者降压治疗48个月后的EQ-5D指数[(0.95±0.07) vs (0.97±0.06),P=0.0027]和EQ VAS [(81.36±12.04)分vs(84.89±9.67)分,P=0.0017]均有显著提高,尤其在焦虑/抑郁和疼痛/不适维度方面改善明显。两组EQ VAS或EQ-5Q指数的差异无统计学意义(P均>0.05)。结论:降压治疗可改善高血压患者HRQo L,尤其是HRQo L的焦虑/抑郁和疼痛/不适维度。氨氯地平联合复方阿米洛利或联合替米沙坦在改善高血压患者HRQo L方面没有差异。Objectives： To compare the impact of different antihypertensive therapy regimens on health-related quality of life（HRQo L） in patients with hypertension.Methods： Current study was a sub-study of Chinese Hypertension Intervention Efficacy Study（CHIEF）,the goal of this study was to compare the effects of different antihypertensive therapy regimens（Amlodipine＋compound amiloride vs amlodipine ＋ telmisartan） in hypertensive patients. The HRQo L of participants was assessed by Euro Qo L five dimensions questionnaire（EQ-5D）, which was composed of EQ VAS and EQ-5D. Results： Among 13 542 participants, 13 499（99.7%） were eligible for analyses. After 48 months of antihypertensive therapy, EQ-5D index（[0.95±0.07] vs [0.97±0.06], P =0.0027） and EQ VAS（[81.36±12.04] vs [84.89±9.67], P =0.0017）increased significantly in all patients compared to baseline levels,there was no significant difference between the two antihypertensive therapy regimens（all P〈0.05）. HRQo L was significantly improved in anxiety/depression and pain/discomfort dimension in all participants. Conclusions： Antihypertensive therapy improves HRQo L of hypertensive patients. Improvement of HRQo L in hypertensive patients is similar between Amlodipine＋compound amiloride and amlodipine ＋ telmisartan regimens.

关 键 词：健康相关生活质量 降压治疗 EuroQoL五维问卷 

分 类 号：R541[医药卫生—心血管疾病]