老年食管癌放化疗结合治疗与单纯放疗治疗的效果与安全性比较  

Comparison of Efficacy and Safety of Radiotherapy and Chemotherapy Combined with Radiotherapy for Elderly Patients with Esophageal Cancer

作　　者：杨玉成 YANG Yu-cheng(Department of Radiotherapy,the First Hospital of Putian,Putian,Fujian Province,351100 China)

机构地区：[1]莆田市第一医院放疗科,福建莆田351100

出　　处：《中外医疗》2018年第24期84-86,共3页China & Foreign Medical Treatment

摘　　要：目的比较老年食管癌放化疗结合治疗与单纯放疗治疗的效果与安全性。方法方便该院2015年1月—2017年4月间收治的66例老年食管癌患者纳入该次实验,采取随机双盲法将其分为实验组(33例)与对照组(33例),实验组患者采取放化疗联合治疗,对照组患者采取单纯放疗治疗,对比两种治疗方案的效果和安全性。结果实验组患者治疗总有效率(81.8%)较对照组(57.6%)更高,组间比较差异有统计学意义(χ~2=4.591,P=0.032);治疗后1年内肿瘤局部控制率(57.6%)较对照组(33.3%)更高,组间比较差异有统计学意义(χ~2=3.911,P=0.048);肿瘤复发率(15.2%)较对照组(36.4%)更低,组间比较差异有统计学意义(χ~2=4.765,P=0.029);不良反应发生率(45.5%)较对照组(18.1%)更高,组间比较差异有统计学意义(χ~2=17.776,P=0.000)。两组患者治疗后1年内生存率无明显区别,组间比较差异无统计学意义(χ~2=2.157,P=0.142)。结论放化疗结合治疗较单纯放疗治疗老年食管癌的疗效更佳,安全性也可接受,更适宜临床推广应用。Objective To compare the efficacy and safety of radiotherapy and chemotherapy combined with radiotherapy forelderly esophageal cancer. Methods 66 elder patients with esophageal cancer admitted to the hospital were included in thisexperiment. The convenient selected cases were from January 2015 to April 2017. They were divided into experimentalgroup （33 cases） and control group （33 cases） by random double-blind method. Patients in the experimental group weretreated with radiotherapy and chemotherapy, and patients in the control group were treated with radiotherapy alone. The efficacy and safety of the two treatment protocols were compared. Results The total effective rate of treatment in the experimental group （81.8%） was higher than that in the control group （57.6%）. The difference between groups was statistically significant （X^2= 4.591, P=0.032）. The local control rate of the tumor within one year after treatment （57.6%） was higher thanthat of the control group （33.3%）, the difference between groups was statistically significant（X^2= 3.911, P=0.048）; tumor recurrence rate （15.2%） lower than the control group （36.4%）, the difference between groups was statistically significant （X^2=4.765, P=0.029）; incidence of adverse reactions （45.5%） was higher than the control group （18.1%）. The difference betweengroups was statistically significant（X^2=17.776, P=0.000）. There was no significant difference in survival rate between the twogroups after one year of treatment. The difference between groups was not statistically significant （X^2=2.157,P=0.142）. Conclusion Radiotherapy and chemotherapy combined with radiotherapy alone is more effective than radiotherapy alone in thetreatment of esophageal cancer in the elderly. The safety is also acceptable. It is more suitable for clinical application.

关 键 词：老年食管癌 放化疗 单纯放疗 治疗效果 安全性 

分 类 号：R5[医药卫生—内科学]