泛素羧基末端水解酶L1(UCHL1)和阿尔茨海默病(AD)的关系  

The relationship of Ubiquitin carboxy terminal hydrolase L1(UCHL1) and Alzheimer's disease(AD)

作　　者：尤年兴[1] 石志革[1] You Nianxing;Shi Zhige(Depazlment of Neurology,the Second People＇s Hospital of Changshou Citv,School of Clinical Medicine in Jiangsu Univezsitv 215501)

机构地区：[1]江苏大学临床医学院,常熟市第二人民医院神经内科,215501

出　　处：《中国社区医师》2018年第28期71-72,共2页Chinese Community Doctors

摘　　要：阿尔茨海默病(AD),又名老年性痴呆,是在老年期发生的一种中枢神经系统变性疾病,其发病机制尚未完全明确。在阿尔茨海默病疾病环境下,神经细胞中蛋白的降解是受损的。本文拟讨论对维持蛋白酶体系统正常功能起重要作用的泛素羧基末端水解酶L1(UCHL1)在阿尔茨海默病发病机制中的作用。Blzheimer＇s disease（AD） also known as Alzheimer＇s disease,is a degenerative disease of the central nervous system in the elderly.Its pathogenesis is not yet clear.In Alzheimer＇s disease,the degradation of protein in nerve cells is impaired.This paper aim to discuss the role of ubiquitin carboxyl terminal hydrolase Ll（UCHL1）,which play-s an important role in maintaining the normal function of the proteasome system in the pathogenesis of Alzheimer＇s disease.

关 键 词：阿尔茨海默病 泛素羧基末端水解酶L1 发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学]