光催化N-芳基化反应的研究进展  

Research progress of photocatalytic N-arylation reaction

作　　者：边启龙 李旭峰 王帅印 夏强强 袁江培 刘俊霞 徐元清[1] 徐浩[1] BIAN Qilong;LI Xufeng;WANG Shuaiyin;XIA Qiangqiang;YUAN Jiangpei;LIU Junxia;XU Yuanqing;XU Hao(College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,Henan,China;Zhejiang Wansheng Co.LTD.,Linhai 317099,Zhejiang,China)

机构地区：[1]河南大学化学化工学院,河南开封475004 [2]浙江万盛股份有限公司,浙江临海317099

出　　处：《化学研究》2018年第5期535-543,共9页Chemical Research

基　　金：河南省教育厅重点攻关项目(135B530916;14A430042;15A150041);河南省科技厅科技攻关项目(14210215010560)

摘　　要：N-芳基化反应作为一类重要的反应,在多种药物分子的合成中有着广泛的应用.高温条件下,过渡金属催化是传统N-芳基化反应的重要手段.光催化作为一种新兴的合成手段,近年来在碳氮键的构建领域发展迅猛.与传统加热方法相比光催化N-芳基化反应具有安全可靠、经济高效、反应条件温和等不可替代的优势.本文主要对近几年利用光催化方法实现N-芳基化反应的研究进展及应用进行了介绍.N-arylation, as an important coupling reaction, has been widely used in the synthesis of drug molecules. Transition metal-catalysis under high temperature condition is an important means to perform N-arylation reaction. As a new synthetic strategy, photocatalysis has been developed rapidly in the construction of carbon-nitrogen bonds in recent years. Compared with the conventional heating method, the photocatalysis method for N-arylation has many advantages such as safety, economic efficiency, and reliability, mild reaction condition. In this paper, the research progress and application of N-arylation by photocatalysis are introduced.

关 键 词：N-芳基化 光催化 研究进展 

分 类 号：O621.3[理学—有机化学]