大黄水煎液灌肠对慢性肾衰竭及微炎症状态的影响  

Efficacy of enema with the Dahuang decoction on chronic renal failure and micro-inflammation

作　　者：温伟伦[1] 吴艳华[1] 蔡兰花[1] 

机构地区：[1]暨南大学医学院第四附属医院|广州市红十字会医院,广东广州510220

出　　处：《中医临床研究》2018年第25期15-17,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:观察在西医治疗的基础上加用大黄水煎液灌肠对慢性肾衰竭及微炎症状态的影响。方法:将60例慢性肾衰竭患者随机分为等例的两组,即治疗组(西药+大黄水煎液灌肠)和对照组(西医疗法)。治疗1个疗程后,观察治疗前后患者尿素氮(BUN)、血肌酐(SCr)、C反应蛋白(CRP)、24h尿蛋白和白细胞介素-6(IL-6)值的变化。结果:SCr、BUN、CRP、24h尿蛋白定量数及IL-6值治疗组治疗前后比较,具有显著性差异(P <0.001或P <0.05);对照组治疗前后对比,具有显著性差异(P <0.05);治疗后患者SCr、BUN、CRP及IL-6值两组组间比较,经统计学处理,P <0.05,具有显著性差异,治疗组优于对照组;治疗后患者24h尿蛋白定量数两组间比较,经统计学处理,P> 0.05,无显著性差异。结论:在西医治疗的基础上加用大黄水煎液灌肠对于慢性肾衰患者具有较好的临床疗效及改善患者微炎症状态,能明显降低SCr、BUN、CRP、24h尿蛋白定量数及IL-6值。Objective： To observe the efect of enema with the Dahuang decoction （大黄水煎液） plus western medicine on chronic renal failure and micro-infammation. Methods： 60 patients with chronic renal failure were randomly divided into two groups. The treatment group was given western medicine plus enema with the Dahuang decoction. The control group was given western medicine. After 1 course, the changes of BUN, SCr, CRP, 24-hour urine protein and IL-6 were observed before and after treatment. Results： SCr, BUN, CRP, 24-hour urinary protein and IL-6 in two group show signifcant diferences between before and after treatment （P〈0.001 or P〈0.05）. SCr, BUN, CRP and IL-6 in the treatment group were better than the control group, with signifcant diferences after treatment （P〈0.05）. There was no signifcant diference in 24-hour urinary protein between two groups after treatment, P〉0.05. Conclusion： Enema with the Dahuang decoction plus western medicine show a better clinical efect, can improve micro-infammation, signifcantly reduce SCr, BUN, CRP, 24-hour urine protein and IL-6.

关 键 词：慢性肾衰竭 大黄 微炎症状态 白细胞介素-6 

分 类 号：R692.5[医药卫生—泌尿科学]