观察微量元素硒对弥漫性毒性甲状腺肿的治疗效果  

Observation of the Therapeutic Effect of Trace Element Selenium on Diffuse Toxic Goiter

作　　者：段玉贞 DUAN Yu-zhen(Department of Endocrinology,Binhu District Chinese Hospital,Wuxi,Jiangsu Province,214121 China)

机构地区：[1]无锡市滨湖区中医院内分泌科,江苏无锡214121

出　　处：《中外医疗》2018年第25期104-105,108,共3页China & Foreign Medical Treatment

摘　　要：目的探讨微量元素硒在治疗弥漫性毒性甲状腺肿中的作用。方法方便筛选该院2016年1月—2018年1月收治的52例弥漫性毒性甲状腺肿患者,随机分为两组,各26例。对照组行常规治疗,观察组加服微量元素硒治疗。评价两组的治疗效果和治疗前后血清相关指标变化情况。结果观察组和对照组临床治疗缓解率分别为92.31%、80.77%,差异有统计学意义(χ~2=5.716 4,P<0.05)。治疗前,两组患者各项指标比较差异无统计学意义(t1=0.231,t2=0.458,t3=1.012,P>0.05);治疗后,两组患者TRAB、TPOAB及IL-6水平分别为(3.68±0.72)IU/L、(65.43±8.24)IU/m L、(15.34±3.88)pg/m L和(5.12±1.08)IU/L、(89.51±6.90)IU/m L、(28.71±6.37)pg/m L,均较治疗前差异有统计学意义(t1=4.896,t2=5.121,t3=5.081,P<0.05),且观察组患者改善情况显著优于对照组,差异有统计学意义(t1=4.685,t2=4.672,t3=5.143,P<0.05)。结论针对弥漫性毒性甲状腺肿可在常规药物治疗基础上加用微量元素硒,可显著改善患者临床症状,治疗效果好,值得推广。Objective To investigate the role of trace element selenium in the treatment of diffuse toxic goiter. Methods A total of 52 patients with diffuse toxic goiter admitted to the hospital from January 2016 to January 2018 were convenient selected and randomly divided into two groups,each with 26 case. The conlrol group received routine treatment, and the observation group was treated with trace element selenium. The treatment effects of the two groups and the changes of serumrelated indicators before and after treatment were evaluated. Results The clinical remission rates of observation group and control group were 92.31% and 80.77%, respectively. The difference was statistically significant （χ2=5.716 4, P〈0.05）. Before treatment, there was no significant difference in each index between the two groups （t1=0.231, t2=0.458, t3=1.012, P〉 0.05）; after treatment, the levels of TRAB, TPOAB and IL-6 in the two groups were （3.68±0.72） IU/L, （65.43±8.24） IU/mL, （15.34±3.88） pg/mL, and （5.12±1.08） IU/L, （89.51±6.90） IU/mL, （28.71±6.37）pg/mL, both were significantly different from those before treatment （t1=4.896, t2=5.121, t3=5.081, P〈0.05）, and the improvement in the observation group was significantly better＇ than that in the control group. The difference was statistically significant （t1=4.685, t2=4.672 , t3= 5.143, P〈0.05）. Conclusion The use of trace element selenium on the basis of conventional drug treatment can significantly improve the clinical symptoms of patients with diffuse toxic goiter, and it is worthy of promotion.

关 键 词：硒 弥漫性毒性甲状腺肿 微量元素 

分 类 号：R581.3[医药卫生—内分泌]