β受体阻滞剂联合ACEI治疗慢性心力衰竭患者疗效分析  

β-blocker Combined with ACEI for the Treatment of Chronic Heart Failure

作　　者：郭敏[1] GUO Min(Zibo Mining Group Co.,Ltd.Central Hospital,Zibo,Shandong Province,255120 China)

机构地区：[1]淄博矿业集团有限责任公司中心医院,山东淄博255120

出　　处：《中外医疗》2018年第25期119-121,共3页China & Foreign Medical Treatment

摘　　要：目的为了提高慢性心力衰竭患者治疗效果,分析采用β受体阻滞剂联合ACEI治疗的价值。方法根据随机原则相关要求从2016年10月—2017年10月在该院治疗的慢性心力衰竭患者中随机抽取144例作为研究对象,借助计算机相关软件将其平均分为观察组和对照组,各72例,其中对照组患者仅给予ACEI治疗治疗,而观察组患者则给予β受体阻滞剂联合ACEI治疗,比较不同治疗方案对疗效和心功能指标的影响。结果研究数据显示,观察组和对照组患者治疗的总有效率分别为97.22%(70/72)和87.50%(63/72),和对照组相比观察组患者治疗的总有效率更占优势,差异有统计学意义(χ~2=4.82,P<0.05);观察组患者治疗后左心射血分数(LVEF)、左室舒张末内径(LVESD)和左室收缩末内径(LVEDD)分别为(50.2±2.3)%、(5.1±0.3)cm、(5.9±0.3)cm,对照组患者治疗后LVEF、LVESD、LVEDD分别为(43.0±2.2)%、(4.2±0.4)cm、(5.1±0.4)cm,观察组患者各心功能指标更占优势,差异有统计学意义(t=10.77、9.86、11.07,P=0.001、0.001、0.001)。结论慢性心力衰竭患者接受β受体阻滞剂联合ACEI治疗,既可以增加治疗效果,又可以改善患者心功能,效果确切,值得推广和应用。Objective To evaluate the value of blockers combined with ACEI therapy in order to improve the therapeutic effect of patients with β-chronic heart failure. Methods A total of 144 patients with chronic heart failure who were treated in the hospital fi＇om October 2016 to October 2017 were randomly selected according to the requirements of the randomization principle. Subjects were randomly divided into observation group and control group with 72 cases by computer-related software. Among them, patients in the control group received only ACE inhibitor therapy, while patients in the observation group received β-blockers combined with ACEI therapy to compare the effects of different treatment strategies on outcomes and cardiac function parameters. Results The study data showed that the total effective rate of treatment in the observation group and the control group were 97.22%（70/72） and 87.50%（63/72）, respectively, and the total effective rate of treatment in the observation group was superior to the control group,the different was statistically significant （χ2=4.82, P〈0.05）; left ventricular ejection fraction （LVEF）, left ventricular end diastolic diameter （LVESD）, and left ventricular end-systolic diameter （LVEDD） were （50.2±2.3）% and （5.1±0.3）cm,（5.9±0.3）cm respectively, in the observation group of LVEF, LVESD, and LVEDD in the control group were （43.0±2.2）%, （4.2±0.4）cm, （5.1±0.4） cm, respectively, and each cardiac function index was observed in the observation group. It is more predominant,the different was statistically significant （t=10.77,9.86,11.07, P= 0.001,0.001,0.001）. Conclusion Patients with chronic heart failure undergoing beta-blocker combined with ACEI therapy can increase the therapeutic effect and improve the heart function of patients. The effect is definite and worthy of promotion and application.

关 键 词：慢性心力衰竭 Β受体阻滞剂 ACEI 心功能指标 疗效 

分 类 号：R541.6[医药卫生—心血管疾病]