幽门螺杆菌和儿童阻塞性睡眠呼吸暂停低通气综合症的相关性研究  

Correlation between Helicobacter pylori and Children Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：涂向东 栗俊杰 姚菲菲 徐洪 庄严 Tu Xiang-dong;Li Junjie;Yao Feifei;Xu Hong;Zhuang Yan(Department of Otorhinolaryngology,the Shekou People＇s Hospital,Shenzhen,518067)

机构地区：[1]深圳市南山区蛇口人民医院耳鼻咽喉科,广东深圳518067

出　　处：《赣南医学院学报》2018年第8期762-765,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：深圳市科创委2015年项目(编号:JCYJ20150403093555005)

摘　　要：目的:探讨幽门螺杆菌感染和儿童阻塞性睡眠呼吸暂停低通气综合症(OSAHS)的相关性。方法:采用特殊染色法、免疫组化检测和聚合酶链反应三种方法联合对53例OSAHS患儿及38例非儿童OSAHS(对照组)进行扁桃体和(或)腺样体手术后组织幽门螺杆菌(Hp)检测。结果:OSAHS组Hp感染阳性率为13. 21%,对照组阳性率5. 26%,两者比较差异无统计学意义(P=0. 370 3)。结论:儿童阻塞性睡眠呼吸暂停综合征的发病可能与咽部组织幽门螺杆菌感染无关,其具体机制尚需进一步的研究。Objective To explore the correlation between Helicobacter pylori infection and Obstructive Sleep Apnea Syndrome in children. Methods Among 91 children whose tissue got from tonsillectomy and/or adenoidectomy surgery all tested in helicobacter pylori detection using Special Staining, Immunohistochemical Detection and Polymerase Chain Reaction together, 53 cases of children with OSAHS as the case group and 38 cases without OSAHS as the control group. Results Hp infection positive rate in OSAHS group was 13.21%, the control group were 5.26%, which shows no statistically significant difference （P 〉 0.3703）, Conclusion The pathogenesis of children with OSAHS may have nothing to do with helicobacter pylori infection, its specific mechanism still needs further research.

关 键 词：阻塞性睡眠呼吸暂停低通气综合症 幽门螺杆菌 儿童 

分 类 号：R563[医药卫生—呼吸系统]