真菌纤维素酶表观遗传修饰的研究进展  

Advances on Epigenetic Modification of Fungi Cellulase

作　　者：郑春娟 邓婷婷 来亚鹏 刘刚 王娟 ZHENG Chun-juan;Deng Ting-ting;La Ya-peng;Liu Gang;Wang Juan(College of Life Sciences and Oceanography,Shenzhen Key Laboratory of Microbial Genetic Engineering,Shenzhen University,Shenzhen 518060,China;College of Life Sciences and Oceanography,Shenzhen Key Laboratory of Marine Bioresources and Ecology,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]深圳大学生命与海洋科学学院,深圳市微生物基因工程重点实验室,广东深圳518060 [2]深圳大学生命与海洋科学学院,深圳市海洋生物资源与生态环境重点实验室,广东深圳518060

出　　处：《纤维素科学与技术》2018年第3期71-77,共7页Journal of Cellulose Science and Technology

摘　　要：组蛋白乙酰化酶编码基因gcn5、蛋白甲基转移酶LaeA及其同源物Lae1、VeA等可通过作用于调节纤维素酶基因及其表达调控因子的表达,进而在转录水平上影响纤维素酶基因的表达。简述了真菌纤维素酶的种类与结构和真菌纤维素酶基因的表达调控机制,重点从DNA甲基化、蛋白甲基化和乙酰化以及非编码RNA等的角度,综述几种主要表观遗传修饰对真菌纤维素酶基因表达作用的研究进展。Studies showned that the histone acetylase gene gcn5, the protein methyltransferase LaeA and its homologs Lae1, VeA may affect the expression of cellulase genes at the transcriptional level by acting on the expression of cellulase genes and their expression regulators. This review focuses on the progress of epigenetic modification on the expression of cellulase in fungi from the perspective of DNA methylation, methylation and acetylation ofprotein, and non-coding RNA.

关 键 词：真菌纤维素酶 DNA甲基化 LAEA 组蛋白乙酰化 SIRNA LncRNA 

分 类 号：Q933[生物学—微生物学]