脉冲电磁场治疗膝骨关节炎的实验研究进展  

Progress in experimental research on pulsed electromagnetic field in the treatment of knee osteoarthritis

作　　者：阳筱甜 何成奇[1] YANG Xiaotian;HE Chengqi(Rehabilitation Medicine Center,West China Hospital,Sichuan Universit;Rehabilitation Key Laboratory of Sichuan Provinc;Chengdu,Sichuan 610041,P.R.China)

机构地区：[1]四川大学华西医院康复医学中心康复医学四川省重点实验室,成都610041

出　　处：《华西医学》2018年第9期1186-1190,共5页West China Medical Journal

基　　金：国家自然科学基金(81372110);四川省科技厅支撑项目(2015SZ0054);成都市科技局项目(2015-HM02-00042-SF)

摘　　要：随着世界以及我国社会人口老龄化的加速,骨关节炎已成为患者和医疗工作者更为关注的健康问题。目前其治疗主要靠药物治疗、手术治疗和康复治疗。脉冲电磁场(pulsed electromagnetic field,PEMF)作为一项安全、无创、简便的治疗方法,已被应用于临床治疗骨质疏松、促进骨折愈合以及改善骨关节炎症状。然而PEMF治疗膝骨关节炎的具体机制尚不明确,据此,该文综述了动物实验中PEMF对膝骨关节炎的细胞凋亡、细胞因子、软骨和软骨下骨的影响,以及细胞实验中软骨细胞形态和细胞外基质的变化,旨在使医疗工作者了解当今PEMF治疗膝骨关节炎基础实验研究的现状与发展方向。With the acceleration of the aging in the world and our society, osteoarthritis has become a health concern for patients and health workers. At present, its treatment mainly relies on drug treatment, surgical treatment and rehabilitation. As a safe, non-invasive and simple treatment, pulsed electromagnetic field（PEMF） therapy has been used in clinical treatment of osteoporosis, promoting fracture healing and improving symptoms of osteoarthritis. However, the mechanism of PEMF in the treatment of knee osteoarthritis is still unclear. This paper reviews the effects of PEMF on apoptosis, cytokines, cartilage and subchondral bone in knee osteoarthritis in animal experiments, and the changes of chondrocyte morphology and extracellular matrix in cell experiments, aiming to enable medical workers to better understand the status and development of PEMF in the treatment of knee osteoarthritis in basic experimental researches.

关 键 词：骨关节炎 脉冲电磁场 康复治疗 

分 类 号：R684.3[医药卫生—骨科学]