局部变应性鼻炎概述  

A brief introduction of local allergic rhinitis

作　　者：胡秋蓉 李靖[1] 

机构地区：[1]广州医科大学附属第一医院过敏与临床免疫科广州呼吸健康研究院呼吸疾病国家重点实验室

出　　处：《临床耳鼻咽喉头颈外科杂志》2018年第17期1363-1366,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金面上项目(No:81370129)

摘　　要：变应性鼻炎（allergic rhinitis,AR）是机体暴露于变应原后主要由IgE介导的鼻黏膜非感染性慢性炎性疾病,其诊断包括典型症状如阵发性喷嚏、清水样涕、鼻痒、鼻塞和至少1种变应原检测试验如变应原皮肤点刺试验（skin prick test,SPT）和（或）血清特异性IgE阳性。若患者症状和AR症状相似,但变应原检测试验均阴性,则诊断为非变应性鼻炎（non-allergic rhinitis,NAR）。Local allergic rhinitis（local allergic rhinitis,LAR）is a newly proposed concept in recent years.It refers to patients with typical allergic rhinitis symptoms but skin prick test（SPT）and serum specificity IgE are negative,while nasal mucosa can produce local specific IgE and allergen provocation test（NAPT）are positive.The rate of clinical misdiagnose is high.The diagnosis mainly relies on typical nasal symptoms,positive NAPT and/or detection of local specific IgE.It needs to be distinguished from allergic rhinitis（AR）and non-allergic rhinitis（NAR）.The main mechanism of its onset is the Th2-type allergic inflammatory response mediated by locally produced IgE.Eosinophils and mast cells are also involved in the inflammatory process.The current study considers LAR to be a separate disease from AR.Allergen immunotherapy（AIT）can be used to treat the disease.

关 键 词：局部变应性鼻炎 免疫球蛋白E 变应原鼻激发试验 发病机制 免疫治疗 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]