甘露聚糖肽两种给药方案预防慢性阻塞性肺疾病急性加重的疗效比较  

Comparison of clinical effect between two types dosage regimen of mannatide in prophylaxis of acute exacerbations of chronic obstructive pulmonary disease

作　　者：马雪丽 徐猛 张艳芳 李肖凯 MA Xueli;XU Meng;ZHANG Yanfang;LI Xiaokai(Traditional Chinese Medicine Hospital of Qixian,Qixian 475200,China)

机构地区：[1]杞县中医院,河南杞县475200

出　　处：《临床医药实践》2018年第10期725-729,共5页Proceeding of Clinical Medicine

摘　　要：目的:比较甘露聚糖肽胶囊两种给药方案预防慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法:选择100例慢性阻塞性肺疾病(COPD)稳定期的患者,按随机数表随机分为A组(50例)和B组(50例)。两组患者均给予甘露聚糖肽胶囊,每次10 mg,每日3次,口服。A组患者连续服用甘露聚糖肽胶囊3个月;B组患者间断服用甘露聚糖肽胶囊3个月,具体方法为:连用10 d,停20 d,再服10 d,停20 d,再服10 d。两组患者均接受沙美特罗替卡松粉吸入剂,每次1吸,每日2次。半年后变更为每次1吸,每日1次,连用12个月。治疗前与治疗3个月后检测免疫学指标(CD4^+、CD8^+、CD4^+/CD8^+、IgA、NK细胞、补体C3),记录两组治疗后12个月内COPD急性加重次数与每次发作抗生素用量。结果:治疗3个月后A组患者的免疫学指标(CD4^+、CD4^+/CD8^+、NK细胞、IgA、补体C3)均高于B组(P <0. 01或P <0. 05),CD8^+平均低于B组(P <0. 05);A组患者的肺功能指标(FEV1、FEV1%、FEV1/FVC、Pa O2)均高于B组(P <0. 05)。治疗后12个月内随访,A组脱落2例,有效28例;B组脱落3例,有效27例。A组急性加重次数少于B组,AECOPD持续时间及抗生素应用时间短于B组(P <0. 01或P <0. 05)。结论:甘露聚糖肽连续给药较间断给药预防AECOPD疗效更好,可提高患者免疫功能,改善肺功能,减少AECOPD的发作次数,缩短发作时间及抗生素应用时间。Objective：To compare the efficacy of two types mannatide dosage regimen in prophylaxis of acute exacerbations of chronic obstructive pulmonary disease（AECOPD）.Methods：All 100 cases patients with stable stage of chronic obstructive pulmonary disease （COPD） were randomly assigned to A group（50 cases）and B group（50 cases）.Two groups were accepted mannatide capsules,10 mg each time,thrice daily,oral.Patients in A group continuous took 3 months of mannatide capsules.Patients in B group intermittent took 3 months of mannatide capsules.The specific method is：took 10 days,stop 20 days,and then took 10 days,stop 20 days,and then took 10 days.Two groups were treated with salmeterol/fluticasone powder inhalation,1 suction each time,2 times daily.Changed to 1 suction each time,once daily after six months,continuous applicated for 12 months.To test immunological parameters（CD4^＋,CD8^＋,CD4^＋/CD8^＋,IgA,NK Cells,complement C3）before treatment and 3 months after treatment,recorded AECOPD times and the amount of antibiotics each time of two groups within 12 months of treatment.Results：The immunological indexes（CD4^＋,CD4^＋/CD8^＋,IgA,NK Cells,complement C3）of patients in A group were higher than those in group B after 3 months（ P 〈0.01 or P 〈0.05）,CD8^＋ average lower than B group（ P 〈0.05）.The lung function indexes（FEV1,FEV1%,FEV1/FVC,PaO 2） of the patients in A group were higher than those in B group（ P 〈0.01 or P 〈0.05）.Follow up for 12 months after treatment.A group shed off 2 cases,valid 28 cases,B group shed off 3 cases,valid 27 cases.The number of acute exacerbation in group A was less than that in group B,the duration of AECOPD and the duration of antibiotics were shorter than that of B group（ P 〈0.05）.Conclusion：The effect of continuous administration of mannatide is better than that of intermittent administration of mannatide in prophylaxis of AECOPD,it can improve the immune function of patients,improve lung function,reduce the frequency of a

关 键 词：甘露聚糖肽 给药方案 预防 慢性阻塞性肺疾病 急性加重 免疫 

分 类 号：R563.9[医药卫生—呼吸系统]