GPCR signaling： conformational activation of arrestins  

作　　者：Alem W. Kahsai Biswaranjan Pan Robert J. Lefkowitz 

机构地区：[1]Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA [2]Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA [3]Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA

出　　处：《Cell Research》2018年第8期783-784,共2页细胞研究（英文版）

摘　　要：The arrestins, a small family of versatile adapter proteins, play central roles in G-protein coupled receptor （GPCR） desensitization, endocytosis, and signal transduction. Two papers by Latorraca et al. and Eichel et al. published recently in Nature, dissect the independent and concerted mechanisms by which the phosphorylated GPCR tail and transmembrane core conformationally enable arrestins to perform their diverse functions.

关 键 词：信号 激活 不敏感性 蛋白质 受体 

分 类 号：Q26[生物学—细胞生物学] TN911.6[电子电信—通信与信息系统]