基于多元统计方法对412例活动期溃疡性结肠炎患者中医症状组合规律研究  

Study on the Combination of TCM Symptoms of 412 Patients with Ulcerative Colitis at Active Stage based on Multivariate Statistical Method

作　　者：刘艳[1] 李毅[1,2] 王小平 唐梦凡[1] 孙婳[1] LIU Yan;LI Yi;WANG Xiao-ping;TANG Meng-fan;SUN Hua(Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi 712046,China;The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang Shaanxi 712000,China)

机构地区：[1]陕西中医药大学,陕西咸阳712046 [2]陕西中医药大学附属医院,陕西咸阳712000

出　　处：《中医药导报》2018年第18期43-46,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：陕西省教育厅研究项目(2017JK0222);陕西中医药大学科研基金项目(2015QN17);陕西省科技厅研究项目(2013JQ4009)

摘　　要：目的:探讨聚类分析和Logistic回归分析在活动期溃疡性结肠炎中医症状组合规律研究中的应用。方法:采用自拟《UC中医证候临床调查表》收集412例活动期溃疡性结肠炎患者的临床症状及体征,并行聚类分析和Logistic回归分析。结果:聚类分析得出活动期溃疡性结肠炎3类基本证候:寒邪客肠证、大肠湿热证、肝郁脾虚证;Logistic回归分析提示:寒邪客肠证主症:泄泻清稀、恶寒发热、泻水样便等,次症:腹痛喜温、痢下白冻、肢体痠痛等;大肠湿热证主症:腹部灼痛、烦热口渴等,次症:痢下赤白脓血、肛门灼热、苔黄腻等;肝郁脾虚证主症:腹部胀痛、与情志有关等,次症:胸胁胀闷、矢气频作、嗳气等。结论:聚类分析与Logistic回归相结合的多元统计方法筛选出活动期溃疡性结肠炎基本中医证候的主要及次要症状,为证候标准化研究探索了一种新的思路。Objective： To explore the application of cluster analysis and logistic regression analysis in the study of TCM syndrome combination rule of active ulcerative colitis. Methods： Using self-made ＂ulcerative colitis TCM epidemiological questionnaire＂, 412 cases of active ulcerative colitis were collected and analyzed by logistic regression and cluster analysis method. Results： The cluster analysis revealed 3 basic syndromes of active ulcerative colitis： stomach cold stagnation syndrome, damp heat syndrome, liver stagnation and spleen deficiency syndrome. Logistic regression analysis showed that the main symptoms of stomach cold stagnation syndrome were：watery diarrhea, fever, diarrhea, watery; the secondary symptoms were： abdominal pain and warm, cold white dysentery, limb pain. The main symptoms of damp heat syndrome were： abdominal burning, fanre thirst, red white dysentery pus, anus, yellow greasy. The main symptoms of liver stagnation and spleen deficiency syndrome were： abdominal pain, abdominal pain, diarrhea and emotion related diarrhea after pain reduction; the secondary symptoms were： chest fullness, vector gas frequency, belching and so on. Conclusion： Cluster analysis and logistic regression were used to screen the main and secondary symptoms of active ulcerative colitis, and it provides a new method for the study of the syndrome standardization of the disease.

关 键 词：溃疡性结肠炎 聚类分析 LOGISTIC回归分析 症状学 证候 

分 类 号：R256.3[医药卫生—中医内科学]