人工肝脏支持系统结合中药治疗疫毒炽盛型重症肝炎的临床疗效  

Clinical Efficacy Observation on Artificial Liver Support System Combined with Traditional Chinese Medicine in Treating Intense Epidemic Toxin Type of Severe Hepatitis

作　　者：刘翔[1] 鹿晓君 Liu Xiang;Lu Xiaojun(Health Management Center,Shiyan People＇s Hospital,Shiyan 442000,China;Department of Geriatrics,Xianyang Center Hospital,Xianyang 712000,China)

机构地区：[1]湖北省十堰市人民医院健康管理中心,十堰442000 [2]陕西省咸阳市中心医院老年病科,咸阳712000

出　　处：《世界中医药》2018年第8期1867-1870,共4页World Chinese Medicine

基　　金：2014年湖北卫生厅科研一般项目(JX6B93)

摘　　要：目的:评价人工肝治疗结合中药汤剂内服治疗疫毒炽盛型重症肝炎患者的相关临床指标,并分析其对疫毒炽盛型重症肝炎的影响。方法:选取2014年9月至2016年2月十堰市人民医院肝病科及内科住院部就诊的疫毒炽盛型重症肝炎患者,共70例。所有患者均进过随机抽取分为观察组和对照组,每组35例。2组患者均进行基础对症治疗,其中观察组加以人工肝支持系统治疗及中药口服治疗,对照组加以人工肝治疗。所有患者均进行8周的治疗,并在治疗前后抽取患者空腹血液对丙氨酸转氨酶(ALT),天冬氨酸转氨酶(AST),总胆红素(TBi L),白蛋白(Alb)、Na+,K+、凝血酶原活动度(PTA)进行检测,观察其治疗的有效率及改善程度。结果:经过8周的治疗后,2组患者除Alb、Na+在治疗前后差异无统计学意义(P>0.05),其ALT、AST、TBi L、Alb、K+、PTA均较治疗前有明显改善(P<0.05),且观察组的改善程度明显优于对照组(P<0.05)。结论:人工肝脏支持系统结合中药治疗疫毒炽盛型重症肝炎,可有效改善患者的肝功能,减轻患者临床症状及体征。Objective： To observe the changes of related clinical indexes in patients with intense epidemic toxin type of severe hepatitis by artificial liver treatment combined with traditional Chinese medicine decoction,and to analyze its effects on intense epidemic toxin type of severe hepatitis. Methods： A total of 70 cases with intense epidemic toxin type of severe hepatitis admitted in our hospital from September 2014 to February 2016 were randomly selected according to random number table method. All patients were randomly divided into test group and control group. Two groups of patients were received symptomatic treatment. The treatment group was treated with artificial liver support system and traditional Chinese medicine decoction,and the control group was treated with artificial liver support system. All patients were treated for 8 weeks. Fasting blood samples before and after treatment of liver function（ ALT,AST,TBil,Alb）,electrolyte（ Na＋,K＋）,coagulation（ PTA） were detected to observe the treatment efficiency and the degree of improvement. Results： After 8 weeks of treatment,Alb and Na＋of two groups showed no significant difference before and after treatment（ P 〉0. 05）,and ALT,AST,TBil,Alb,K＋and PTA were significantly improved compared with before treatment（ P 〈0. 05）. The degree of improvement in the treatment group was significantly better than the control group（ P 〈0. 05）. Conclusion： The liver function of artificial liver support system combined with traditional Chinese medicine in treating patients with intense epidemic toxin type of severe hepatitis,can relieve the clinical symptoms and signs,which is worthy of clinical application research.

关 键 词：人工肝脏支持系统 中药 疫毒炽盛 重症肝炎 肝功能 电解质 临床疗效 中西医结合 

分 类 号：R242[医药卫生—中医临床基础] R575.1[医药卫生—中医学]