葛根素注射液治疗糖尿病周围神经病变的疗效及对肌电图、血液流变学的影响  

Clinical Efficacy of Puerarin Injection in the Treatment of Diabetic Peripheral Neuropathy and the Influence on Electromyogram and Hemorheology

作　　者：王凌霄[1] 温宏峰[1] 才丽娜[1] 李文雅[1] Wang Lingxiao;Wen Hongfeng;Cai Lina;Li Wenya(Neurology Department,Beijing Space Center Hospital,Beijing 100049,China)

机构地区：[1]北京航天中心医院神经内科,北京100049

出　　处：《世界中医药》2018年第8期1929-1932,共4页World Chinese Medicine

基　　金：2017首都临床特色应用研究(z171100001017137)

摘　　要：目的:探讨葛根素注射液治疗糖尿病周围神经病变(DPN)的疗效及对肌电图、血液流变学的影响。方法:选取2014年11月至2017年2月北京航天中心医院收治的DPN患者96例,随机分为观察组与对照组,每组48例,对照组采用α-硫辛酸治疗,并控制饮食、口服降糖药物等;观察组在对照组基础上结合葛根素注射液治疗,2组均连续治疗2个月。比较2组患者临床疗效、治疗前后周围神经病变的症状评分(TSS)、肌电图及血液流变学指标变化。结果:治疗后观察组与对照组的总有效率为分别为91.67%、81.25%,观察组显著高于对照组(P<0.05);与治疗前比较,治疗后2组患者麻木、刺痛、抽筋、乏力等TSS评分及全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)、血细胞比容(HCT)、血小板聚集率均显著下降(P<0.05),且观察组明显低于对照组(P<0.05);与治疗前比较,治疗后2组患者正中神经和腓总神经的感觉传导速度(SNCV)、运动传导速度(MNCV)均显著提高,且观察组明显高于对照组(P<0.01)。结论:葛根素治疗DPN可有效缓解患者临床症状,改善其血液流变学及肌电图,临床疗效优于单用西药治疗。Objective： To explore the clinical efficacy of puerarin injection in the treatment of diabetic peripheral neuropathy（ DPN） and the influence on electromyogram and hemorheology. Methods： A total of 96 cases of DPN patients from November 2014 to February 2017 were selected and randomly divided into observation group（ n = 48） and control group（ n = 48）. The control group was treated by α-lipoic acid with limited diet and hypoglycemic agents by or administration. The observation group was treated with puerarin injection on the basis of treatment in the control group. Both groups were treated for 2 months continuously. Comparison was made on the clinical efficacy,the symptom scores of peripheral neuropathy（ TSS） and the change of electromyogram and hemorheology in 2 groups before and after treatment. Results： The total effective rate was 91. 67% in observation group,which was significantly higher than 81. 25% in control group（ P 〈0. 05）. Compared with the scores before the treatment,the TSS scores including numbness,tingling,cramps,weakness,and the HSV,LSV,PSV,HCT as well as platelet aggregation rate of 2 groups were significantly decreased after the treatment（ P 〈0. 05 or P 〈0. 01）. And the observation group was evidently lower than the control group（ P 〈0. 01）. Compared with statics before the treatment,the MNCV,SNCV of median nerve and common peroneal nerve of 2 groups were obviously increased after the treatment,and the observation group was evidently higher than the control group（ P 〈0. 01）. Conclusion： In the treatment of DPN,puerarin injection can significantly relief the clinical symptoms of patients,improve the electromyogram and hemorheology,and the clinical efficacy is better than western medicine alone.

关 键 词：糖尿病 周围神经病变 葛根素注射液 疗效 肌电图 血液流变学 

分 类 号：R242[医药卫生—中医临床基础] R284[医药卫生—中医学]