史大卓教授治疗介入后冠心病遣方用药规律的关联性分析  

Correlation Analysis of the Rules of Prescription and Medication of Coronary Heart Disease after Percutaneous Transluminal Coronary Intervention Treated by Professor Shi Dazhuo

作　　者：柴华[1,2] 张璇 曲华[1,2] 李金根[1] 姜众会 高铸烨 史大卓 Chai Hua;Zhang Xuan;Qu Hua;Li Jingen;Jiang Zhongbui;Gao Zhuye;Shi Dazhuo(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;China Academy of Chinese Medical Sciences,Beijing 100700,China;Haidian District Hospital of Traditional Chinese Medicine,Beijing 100086,China)

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]中国中医科学院,北京100700 [3]北京市海淀区中医医院,北京100086

出　　处：《世界中医药》2018年第8期1957-1960,共4页World Chinese Medicine

基　　金：国家十二五科技支撑计划项目(2013BAI02B01)--基于病证结合降低冠心病稳定期心血管事件的临床研究;中国中医科学院苗圃课题(ZZ11-066)--基于Choline/TMA/TMAO代谢通路研究黄连素抗动脉粥样硬化机制

摘　　要：目的:基于数据挖掘技术分析史大卓教授辨治介入后冠心病的遣方用药特点和规律。方法:利用关联规则分析,采用WEKA实现的Apriori算法(即Agrawal研究提出的算法),进行中药组方配伍的关联规则知识发现。结果:史教授辨治介入后冠心病常用的中药配伍有:莪术配丹参、赤芍配丹参、黄连配丹参、莪术配赤芍、川芎配丹参、生黄芪配丹参、莪术配川芎;常用的多个药物配伍(药组)有:川芎、莪术、赤芍、丹参,莪术、赤芍、丹参,川芎、黄连、赤芍、丹参,莪术、川芎、丹参,莪术、川芎、赤芍,赤芍、生黄芪、川芎、丹参,黄连、丹参、赤芍,赤芍、川芎、丹参,黄连、川芎、丹参等。结论:史教授治疗介入后冠心病常用的重要组方配伍为丹参、赤芍、黄连、川芎、生黄芪,体现了他临床善用益气、活血、解毒的遣方用药特点。Objective： To summary the characteristics and principles of prescription and medication of coronary heart disease（ CHD） after percutaneous transluminal coronary intervention（ PCI） that diagnosed and treated by Professor Shi Dazhuo. Methods： Using the association rule analysis,the Apriori algorithm implemented by WEKA（ the algorithm proposed by Agrawal research） was used to discover the knowledge of association rules of Chinese medicine prescription compatibility. Results： The common compatibility of Chinese herbs used by Professor Shi was as follows： Rhizoma Curcumae with Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra with Radix Salviae Miltiorrhizae,Rhizoma Coptidis with Radix Salviae Miltiorrhizae,Rhizoma Curcumae with Radix Paeoniae Rubra,Rhizoma Ligustici Chuanxiong with Radix Salviae Miltiorrhizae,Radix Astragali seu Hedysari with Radix Salviae Miltiorrhizae,Rhizoma Curcumae with Rhizoma Ligustici Chuanxiong. Drug groups commonly used were Rhizoma Ligustici Chuanxiong,Rhizoma Curcumae,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizoma Curcumae,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizoma Ligustici Chuanxiong,Rhizoma Coptidis,Radix Paeoniae Rubra,Radix Salviae Miltiorrhizae; Rhizoma Curcumae,Rhizoma Ligustici Chuanxiong,Radix Salviae Miltiorrhizae; Rhizoma Curcumae,Rhizoma Ligustici Chuanxiong,Radix Paeoniae Rubra; Radix Paeoniae Rubra,Radix Astragali seu Hedysari,Rhizoma Ligustici Chuanxiong,Radix Salviae Miltiorrhizae; Rhizoma Coptidis,Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra; Radix Salviae Miltiorrhizae,Rhizoma Ligustici Chuanxiong,Radix Salviae Miltiorrhizae; Rhizoma Coptidis,Rhizoma Ligustici Chuanxiong,Radix Salviae Miltiorrhizae and so on. Conclusion： Professor Shi commonly used compatibility of Chinese herbs in the treatment of CHD are as follows： Radix Salviae Miltiorrhizae,Radix Paeoniae Rubra,Rhizoma Coptidis,Rhizoma Ligustici Chuanxiong,Radix Astragali seu Hedysari. The results revealed that Professor Shi focused on tonifying qi,promoting blood

关 键 词：关联规则 介入后冠心病 遣方用药规律 

分 类 号：R249[医药卫生—中医临床基础] R259[医药卫生—中医学]