Comparison of Electroacupuncture and Mild-Warm Moxibustion on Brain-Gut Function in Patients with Constipation-Predominant Irritable Bowel Syndrome: A Randomized Controlled Trial  

作　　者：ZHAO Ji-meng1 LU Jin-hua2 YIN Xiao-jun1 WU Lu-yi1 BAO Chun-hui1 CHEN Xing-kui3 CHEN Yue-hua4 TANG Wei-jun1 JIN Xiao-ming6 WU Huan-gan1 SIll Yin1 ZHAO Ji-meng;LU Jin-hua;YIN Xiao-jun;WU Lu-yi;BAO Chun-hui;CHEN Xing-kui;CHEN Yue-hua;TANG Wei-jun;JIN Xiao-ming;WU Huan-gan;SHI Yin

机构地区：[1]Shanghai Research Institute of Acupuncture-Moxibustion and Meridian, Shanghai University of Traditional Chinese Medicine [2]Medical Imaging Department, Jinhua Municipal Central Hospital [3]Department of Acupuncture and Moxibustion, Jinhua Municipal Central Hospital [4]Department of Digestive System, Jinhua Municipal Central Hospital [5]Radiology Department, Huashan Hospital, Fudan University [6]Department of Anatomy and Cell Biology, Indiana University School of Medicine

出　　处：《Chinese Journal of Integrative Medicine》2018年第5期328-335,共8页中国结合医学杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.30973784);the National Basic Research Program of China,973 program(No.2009CB522900)

摘　　要：Objective： To compare the effects of electroacupuncture （EA） and mild-warm moxibustion （Mox） therapies for constipation-predominant irritable bowel syndrome （C-IBS） patients. Methods： Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group （30 cases） and Mox group （30 cases）. Both EA and Mox treatments were performed on bilateral Tianshu （ST 25） and Shangjuxu （ST 37） for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex （ACC）, insular cortex （IC） and prefrontal cortex （PFC） were observed by functional magnetic resonance imaging （fMRI） before and after treatment. Results： Compared with the Mox group, greater improvements in abdominal distension, defecation frequency, difficulty in defecation and stool features were observed in the EA group （all P〈0.01）, both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly decreased in the EA group （all P〈0.01）. Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation （P〈0.05 or P〈0.01）. Conclusions： Both EA and Mox could significantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. （Registration No. ChiCTR- TRC-11001349）.Objective： To compare the effects of electroacupuncture （EA） and mild-warm moxibustion （Mox） therapies for constipation-predominant irritable bowel syndrome （C-IBS） patients. Methods： Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group （30 cases） and Mox group （30 cases）. Both EA and Mox treatments were performed on bilateral Tianshu （ST 25） and Shangjuxu （ST 37） for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex （ACC）, insular cortex （IC） and prefrontal cortex （PFC） were observed by functional magnetic resonance imaging （fMRI） before and after treatment. Results： Compared with the Mox group, greater improvements in abdominal distension, defecation frequency, difficulty in defecation and stool features were observed in the EA group （all P〈0.01）, both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly decreased in the EA group （all P〈0.01）. Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation （P〈0.05 or P〈0.01）. Conclusions： Both EA and Mox could significantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. （Registration No. ChiCTR- TRC-11001349）.

关 键 词：irritable bowel syndrome CONSTIPATION ELECTROACUPUNCTURE MOXIBUSTION randomized controlled trial 

分 类 号：R246.1[医药卫生—针灸推拿学]