Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs  

作　　者：Dan Luo Yan Shen Jian-Qiang Lyu Yong-Qian Fan Dong-Hui Huang Wei-Long Lin Hai-Min Shen Hu-Ji Xu Jian-Long Guan 

机构地区：[1]Department of Rheumatology, Huadong Hospital, Fudan University, Shanghai 200040, China [2]Key Laboratory of Exercise and Health Sciences of Ministry of Education, School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China [3]Department of Orthopedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China [4]Department of Rheumatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China [5]Department of Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China

出　　处：《Chinese Medical Journal》2018年第18期2229-2231,共3页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China （No. 81072478 and No. 81273298） and Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines （No. 2015ZB0501 ）.

摘　　要：To the Editor： Osteoarthritis （OA） has the highest prevalence and economic impact among arthritic maladies and is the most common cause of long-term disability among individuals over 65 years of age. OA is characterized by the degeneration of articular cartilage and the loss of cartilage matrix in affected joints. It is widely accepted that an imbalance between the biosynthesis and the degradation of extracellular matrix （ECM） occurs in OA cartilage.To the Editor： Osteoarthritis （OA） has the highest prevalence and economic impact among arthritic maladies and is the most common cause of long-term disability among individuals over 65 years of age. OA is characterized by the degeneration of articular cartilage and the loss of cartilage matrix in affected joints. It is widely accepted that an imbalance between the biosynthesis and the degradation of extracellular matrix （ECM） occurs in OA cartilage.

分 类 号：Q51[生物学—生物化学] TQ172.622[化学工程—水泥工业]