以高热为表现的外源性脂质性肺炎1例  

Exogenous lipid pneumonia with hyperpyrexia: a case report

作　　者：吴小静[1] 李敏[1] 詹庆元[1] WU Xiao-jing;LI Min;ZHAN Qing-yuan(Department of Pulmonary and Critieal Care Medieine,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院呼吸与危重症医学科,北京100029

出　　处：《北京大学学报（医学版）》2018年第5期921-923,共3页Journal of Peking University:Health Sciences

基　　金：北京市科技计划课题首都临床特色应用研究与成果推广项目(Z161100000516116)~~

摘　　要：脂质性肺炎（lipoid pneumonia,LP）是一种由于类脂物质在肺内集聚引起的非常见疾病,根据脂类物质来源不同,可分为内源性脂质性肺炎（endogenous lipoid pneumonia）和外源性脂质性肺炎（exogenous lipoid pneumonia）。内源性脂质性肺炎又叫“胆固醇肺炎”或“黄金肺炎”,类脂物质由肺组织自身产生）,多见于未分化性结缔组织病、原发性硬化性胆管炎及肺泡蛋白沉积症。Lipoid pneumonia （LP） is an uncommon form of pneumonia that is characterized by the presence of intra-alveolar lipid and lipid-laden macrophages on microscopy. It categorized as exogenous lipoid pneumonia （ExLP） and endogenous lipoid pneumonia （EnLP）. Exogenous lipoid pneumonia caused by inhalation of liposuction substances （animal fat,vegetable oil,or mineral oil）,mostly,in adult cases,they were medicines for constipation or rhinopharyngitis. Most of these patients showed mild clinical manifestations,and chronic medical condition. There were reports of lipoid pneumonia being successfully treated with corticosteroids,immunoglobulins and whole lung lavage. We report a case of exogenous lipoid pneumonia characterized by high fever and acute medical condition. A 77-year-old woman with hypertension and diabetes mellitus,accepted paraffin oil treatment for ＂incomplete intestinal obstruction＂,then,an accident of aspiration happened,as she went through the history of coughing while eating,followed by persistent hyperthermia and increases of white blood cells （WBC）. Chest CT showed progressive ground-glass opacities,accompanied with fusion of consolidation,her sputum etiological examination was negative,and the therapy of broad-spectrum antibiotic was invalid. The patient was subjected to bronchofibroscopy with bronchoalveolar lavage （BAL）. The bronchoalveolar lavage fluid （BALF） appeared colorless and transparent,and did not show a milky appearence. Total cell count of the BALF was 2. 0 × 10^5 cell/m L,including 7. 2% macrophages and 92. 8% neutrophils. Cultures of the BALF were negative for bacterial,fungal,and mycobacterial pathogens. The BALF cytologic findings showed vacuolated lipid-laden macrophages （Oil Red O staining）. These findings revealed exogenous lipoid pneumonia. There were reports of lipoid pneumonia being successfully treated with corticosteroids,immunoglobulins,and whole-lung lavage. So this patient was treated with methylprednisolone 120 mg/d for 3 days and 80 mg/d

关 键 词：肺炎 吸入性 肺炎 脂质性 高热 支气管肺泡灌洗 

分 类 号：R563.1[医药卫生—呼吸系统]