CPIS、PCT和D-二聚体对新生儿RDS并发呼吸机相关性肺炎预后评估的价值分析  

THE VALUE OF CPIS, PCT AND D DIMER IN PROGNOSIS EVALUATION OF NEONATAL RDS COMPLICATED WITH VENTILATOR-ASSOCIATED PNEUMONIA

作　　者：张少雨[1] 刘秀兰[1] 孟林[1] 桑艳锋 张冬梅[1] 刘咏梅[1] ZHANG Shao-Yu;LIU Xiu-lan;MENG Lin(Pediatric Department of Chengde Central Hospital,Hebei Chengde 067000,China)

机构地区：[1]承德市中心医院儿科,河北承德06700

出　　处：《承德医学院学报》2018年第5期380-383,共4页Journal of Chengde Medical University

基　　金：承德市科技局项目(201601A012)

摘　　要：目的:探讨临床肺部感染评分(CPIS)、D二聚体、降钙素原(PCT)对新生儿呼吸窘迫综合征(RDS)并发呼吸机相关性肺炎(VAP)预后评估的价值。方法:131例新生儿RDS并发VAP患儿根据病情转归分为生存组(75例)和死亡组(56例),记录所有患儿诊断VAP后第1天、第3天、第5天的CPIS评分、PCT和D二聚体水平。结果:诊断第3天、第5天,死亡组患儿的CPIS评分、D-二聚体、PCT均明显高于生存组,差异具有统计学意义(P<0.05)。随着诊断时间的延长,生存组患儿CPIS评分、D-二聚体、PCT逐渐降低(P<0.05),死亡组患儿CPIS评分、D-二聚体、PCT逐渐升高(P<0.05)。结论:监测CPIS评分、PCT、D-二聚体对新生儿RDS并发VAP的预后评估具有较好的临床价值。bObjective： To investigate the value of clinical pulmonary infection score （CPIS）, D dimer and procalcitonin （PCT） in prognosis evaluation of neonatal respiratory distress syndrome （RDS） complicated with ventilator associated pneumonia （VAP）. Methods： 131 cases of neonatal RDS complicated with VAP children were divided into survival group （n=75） and death group （n=56） according to the disease prognosis. The CPIS, PCT and D dimer of all the children at the frst, third and ffth day of diagnosis were recorded. Results： At the third and ffth day of diagnosis, the CPIS, PCT and D dimer of children in death group were all obviously higher than survival group （ P〈0.05）. With the prolongation of diagnosis time, the CPIS, PCT and D dimer of children in survival group decreased gradually （ P〈0.05）, while the CPIS, PCT and D dimer of children in death group increased gradually （ P〈0.05）. Conclusions： Monitoring CPIS, PCT and D dimers have good clinical value in predicting the prognosis of neonatal RDS complicated with VAP.

关 键 词：新生儿 呼吸窘迫综合征(RDS) 呼吸机相关性肺炎(VAP) 临床肺部感染评分(CPIS) 降钙素原(PCT) D-二聚体 

分 类 号：R722.1[医药卫生—儿科]