锰超氧化物歧化酶基因Val(16)Ala(rs4880)多态性与糖尿病视网膜病变发生风险相关性的Meta分析  

Meta-analysis of the association between the polymorphism of manganese superoxide dismutase gene Val(16)Ala(rs4880) and the risk of diabetic retinopathy

作　　者：黄磊[1] 柳青青 贺海蓉 刘秋平[1] 陈承[1] 王彤[1] 吕军[2] HUANG Lei1, LIU Qing-qing2, HE Hai-rong2, LIU Qiu-ping1, CHEN Cheng1, WANG Tong1, LV Jun 2(1. Ophthalmology Department, Xi＇an No.1 Hospital, Xi＇an 710002; 2. Clinical Research Center, the First Affiliated Hospital ofXi＇an Jiaotong University, Xi＇an 710061, China)

机构地区：[1]西安市第一医院眼科,陕西西安710002 [2]西安交通大学第一附属医院临床研究中心,陕西西安710061

出　　处：《临床医学研究与实践》2018年第28期1-4,共4页Clinical Research and Practice

基　　金：国家社会科学基金一般项目(No.16BGL183)

摘　　要：目的探讨锰超氧化物歧化酶(MnSOD)基因Val(16)Ala(rs4880)的多态性是否与糖尿病视网膜病变(DR)的发生风险有关。方法计算机检索PubMed、EMBASE和Cochrane library等外文数据库以及中国知网、维普和万方等中文数据库。两位评价员按照纳入与排除标准独立筛选文献、提取资料和评价纳入研究的方法学质量。本研究采用Stata14.0软件进行Meta分析;使用敏感性分析衡量研究结果的稳健性;使用Egger线性回归和Begg漏斗图来分析发表偏倚程度;通过亚组分析探讨异质性来源。结果本研究纳入的10篇文献中病例组1 500例和对照组1 330例。Meta分析结果显示,MnSOD基因Val(16)Ala(rs4880)多态性与加性模型(OR=0.76,P=0.02)和隐性模型(OR=0.60,P=0.04)下DR发生风险相关。亚组分析结果表明,在亚洲人种中,MnSOD基因Val(16)Ala(rs4880)多态性与DR发病风险有关(P=0.03,P<0.01);基因分型检测方法可能是MnSOD基因Val(16)Ala(rs4880)多态性与DR之间关系异质性的来源。漏斗图及Egger线性回归结果表明,在加性模型(P=0.59)、显性模型(P=1.00)及隐性模型(P=0.99)中纳入的10篇文献均无明显偏倚。结论本研究发现,在亚洲人群中,MnSOD基因Val(16)Ala(rs4880)多态性是DR发生的危险因素,因此临床应重点关注这些易感基因的携带者。Objective To investigate whether the polymorphism of manganese superoxide dismutase （MnSOD） gene Val（16）Ala（rs4880） is associated with the risk of diabetic retinopathy （DR）. Methods Retrieval of foreign language databases includingPubMed, EMBASE, Cochrane library and Chinese databases such as CNKI, VIP and Wanfang were carried out by computer.Two evaluators independently screened the literature, extracted data and evaluated the methodological quality of the includedliterature according to inclusion and exclusion criteria. In this study, Stata 14.0 software was used for meta -analysis;sensitivity analysis was used to measure the robustness of the literature results; Egger＇s linear regression and Begg＇s funnelplot were used to analyze the degree of publication bias, and subgroup analysis was used to explore the sources ofheterogeneity. Results Of the 10 articles included in this study, 1 500 cases were case group and1 330 cases were controlgroup. The Meta-analysis results showed that the polymorphism of MnSOD gene Val（16）Ala（rs4880） was associated with therisk of DR in additive model （OR=0.76, P=0.02） and recessive model（OR=0.60, P=0.04）. Subgroup analysis results showedthat the polymorphism of MnSOD gene Val （16）Ala（rs4880） was associated with the risk of DR in Asians（P=0.03, P〈0.01）,and the genotyping test method might be the source of the heterogeneity between the polymorphism of MnSOD gene Val（16）Ala （rs4880） and DR. The results of Begg＇s funnel plot and Egger＇s linear regression showed that there were no significant biasesin the 10 included literatures in the additive model（P=0.59）, the dominant model（P=1.00） and the recessive model（P=0.99）.Conclusion The study find that the polymorphism of MnSOD gene Val （16）Ala （rs4880） is a risk factor for DR in Asian,therefore clinical should pay attention to the carriers of these susceptible genes.

关 键 词：锰超氧化物歧化酶(MnSOD) 基因多态性 糖尿病视网膜病变(DR) 

分 类 号：R587.1[医药卫生—内分泌]