虚拟心脏仿真研究进展及其在临床中的应用  

Research progress of virtual heart simulation and its applications in clinic

作　　者：田亚琴[1] 窦建洪[1] 夏灵[2] 黄伟毅[1] TIAN Yaqin;DOU Jianhong;XIA Ling;H HUANG Weiyi(Guangzhou General Hospital of Guangzhou Military Command,Guangzhou 510010;Zhejiang University,Hangzhou 310027)

机构地区：[1]广州军区广州总医院,广州510010 [2]浙江大学,杭州310027

出　　处：《北京生物医学工程》2018年第5期545-550,共6页Beijing Biomedical Engineering

基　　金：国家自然科学基金青年科学基金项目(31100671);国家自然科学基金重大科研仪器研制项目(61527811);广州市科技计划项目产学研协同创新重大专项(201704020078)资助

摘　　要：虚拟心脏就是利用计算机来模拟心脏的生理结构及功能,对心血管疾病的研究有重要意义。目前在心脏的各种仿真研究中,不同学科的研究小组所用的计算机模型相差较大,尚无统一的跨学科研究平台。本文从微观层次和宏观层次综述了虚拟心脏在功能性建模方面的研究进展,并对心脏疾病的模拟仿真以及虚拟心脏在临床上的应用进行了综述。最后,简要地分析了虚拟心脏建模在临床应用中的优势,并对虚拟心脏发展方向进行了展望。虚拟心脏可以定量分析所有对心脏疾病诊断和治疗极为有价值的生理信息,从而系统地揭示心脏内部运行的机制,它是现代医学科学发展的重要方向。Virtual heart can be used to investigate the physiological structure and function of heart by computer, and play an important role to the research of heart diseases. At present, a unified interdisciplinary research platform has not been constructed due to the complexity of heart modeling and simulation. From the micro level and the macro level, we summarize the recent research achievements and progress of functional modeling of virtual heart. The heart diseases simulation and the applications of virtual heart in clinic are also described at full length. Finally, the advantage of virtual heart modeling in clinical applications and the research trend are discussed. Virtual heart will provide all valuable physiological information useful to the diagnosis and therapy of heart diseases quantitatively and reveal the cardiac internal operation mechanism systematically. Virtual heart significantly oriented the development direction of modern medical science.

关 键 词：虚拟心脏 建模仿真 解剖数学模型 心脏电力学复合模型 临床应用 

分 类 号：R318.04[医药卫生—生物医学工程]