卡介苗对结核性胸膜炎的免疫保护作用  

Study on the immunoprotection of BCG against tuberculous pleurisy

作　　者：张正玲[1] 张翊玲[2] 姚红梅[2] 徐琳[2] 钱正敏[1] 吴莉莉[1] ZHANG Zheng - ling, ZHANG Yi - ling, YAO Hong - mei, XU Lin, QIAN Zheng - min, WU Li - li(College of Biology and Agriculture, Zunyi Normal University, Zunyi 563002, China)

机构地区：[1]遵义师范学院生物与农业科技学院,贵州遵义563002 [2]贵州省人民医院呼吸与危重症医学科国家呼吸疾病临床医学研究中心核心单位,贵州贵阳550002

出　　处：《广东医学》2018年第18期2754-2757,共4页Guangdong Medical Journal

基　　金：贵州省科技合作计划项目(编号:黔科合LH字[2015]7034号)

摘　　要：目的结核性胸膜炎是结核病中最为常见的类型,为了解接种卡介苗后是否对结核胸膜炎有一定的预防保护作用,对卡介苗的防护作用作更进一步认识,为新型结核疫苗类似的评估提供一定理论依据。方法通过严格排除影响因素后按标准入选,患者分为两组,一组为接种卡介苗组,一组为未接种卡介苗组,通过比较接种卡介苗与未接种卡介苗患者的结核性胸膜炎其T淋巴细胞斑点数(T-SPOT)、胸腔积液细胞总数、胸腔积液生化、胸腔积液量及严重程度、治疗效果及预后等方面进行综合分析,了解接种卡介苗与未接种卡介苗的两组之间是否存在差异。结果两组进行对比,未接种卡介苗组的结核性胸膜炎患者的TSPOT斑点数、胸腔积液细胞总数、胸腔积液生化、血沉、C反应蛋白(CRP)等均较接种卡介苗组的结核性胸膜炎患者显著增高,而其受教育程度低、大多来自农村,需要有效的抗结核治疗时间延长,两组之间差异有统计学意义(P <0. 05)。结论贵州地区接种卡介苗对结核胸膜炎具有一定的免疫保护作用。Objective To understand whether Bacillus calmette guerin（ BCG） vaccination has a protective effect against tuberculous pleurisy,thus to provide a theoretical basis for the new TB vaccine. Methods By strictly excluding the influencing factors according to the standard selection,the patients were divided into two groups,BCG vaccination group and non-vaccinated group. The spots in T-SPOT,pleural fluid cell count,pleural effusion volume and inflammatory severity,treatment efficacy and prognosis were compared between the two groups. Results Compared with BCG vaccination group,the spots in T-SPOT,pleural fluid cell count,pleural effusion volume,erythrocyte sedimentation and CRP in tuberculous pleurisy patients without BCG vaccination were significantly higher. Low education and raising in rural areas were significantly more often in non-vaccination group（ P〈 0. 05）. Conclusions Bacillus calmette guerin has a certain protective effect on tuberculosis pleurisy.

关 键 词：卡介苗 结核性胸膜炎 T-SPOT 免疫保护 

分 类 号：R521.7[医药卫生—内科学]