黄连素及益生菌改善二甲双胍肠道不耐受性的疗效分析  

Curative effect analysis of Berberine and Probiotics in improving intestinal intolerance of Metformin

作　　者：任婷婷 索丽霞 陈晓鸥 杨玮 汤明明 李学庆 REN Ting-ting;SUO Li-xia;CHEN Xiao-ou(Department of Endocrinology,Jiading District Central Hospital Affiliated Shanghai University of Medicine ＆ Health Sciences,Shanghai 201800,China)

机构地区：[1]上海健康医学院附属嘉定区中心医院内分泌科,201800 [2]上海健康医学院附属嘉定区中心医院药剂科,201800

出　　处：《中国现代药物应用》2018年第19期1-4,共4页Chinese Journal of Modern Drug Application

基　　金：上海市区卫计委课题(项目编号:20134327)

摘　　要：目的探讨黄连素及益生菌用于改善二甲双胍肠道不耐受性的临床疗效和安全性。方法 80例首次服用二甲双胍后出现腹泻的2型糖尿病患者为观察对象,按照随机数字表法分为A组、B组、C组、D组,各20例。四组均维持原降糖方案,在此基础上,A组采用黄连素干预,B组采用益生菌干预,C组采用黄连素联合益生菌干预。比较四组疗效。结果干预3 d及1周时,A、B、C组总有效率及显效率均高于D组,差异均有统计学意义(P<0.05);A、B、C三组显效率两两比较,差异均无统计学意义(P>0.05)。四组组内干预3 d及1周总有效率比较,差异均无统计学意义(P>0.05)。A组及D组组内干预3 d及1周显效率比较,差异均无统计学意义(P>0.05);B组及C组组内干预3 d及1周显效率比较,差异均有统计学意义(P<0.05)。停用干预药物1个月后随访,其中11例失访,余38例显效患者中2例患者再次发生腹泻,分别为采用黄连素药物及联合药物治疗者。干预1周后,四组空腹血糖(FPG)水平均较本组干预前降低,差异均有统计学意义(P<0.05);干预1周后四组间比较,差异均无统计学意义(P>0.05)。A、B、C三组患者治疗期间均未见明显不良反应,治疗前、治疗中及治疗后血常规、粪常规及肝肾功能检查未见明显异常。结论黄连素及益生菌均可改善二甲双胍肠道不耐受性,且安全性高,值得在临床上予以推广。Objective To investigate the clinical efficacy and safety of Berberine and Probiotics in improving intestinal intolerance of Metformin. Methods A total of 80 patients with type 2 diabetes who had diarrhea after Metformin treatment for the first time were selected as research objects, they were divided into group A, group B, group C and group D, according to the random number table method. 20 cases in each group. All four groups maintained the original hypoglycemic regimen. On this basis, the group A was treated with Berberine for intervention, the group B was treated with Probiotics for intervention, the group C was treated with Berberine combined with Probiotics for intervention. The curative effects of the four groups were compared. Results The total effective rate and marked effective rate in the group A, B and C at 3 days and 1 week after intervention were significantly higher than those in group D, the differences were statistically significant（P〈0.05）. Three groups were compared pairwise. There were no significant differences in the marked effective rate of group A, group B and group C（P〉0.05）. There were no significant differences in the total effective rate among the four groups at 3 days and 1 week after intervention（P〉0.05）. Compared within groups, there were no significant differences in the marked effective rate between the 3 days and 1 week after intervention in group A and group D（P〉0.05）. Compared within groups, there were significant differences in the marked effective rate between the 3 days and 1 week after intervention in group B and group C（P〈0.05）. One month after discontinuation of intervention drugs, 11 cases of them were missing, 2 cases of remaining 38 patients with significant effect occurred diarrhea again, which were treated with Berberine and combination drugs respectively. After 1 week of intervention, the fasting blood glucose（FPG） levels of the four groups were significantly lower than those before intervention, the differences were statistically s

关 键 词：糖尿病 二甲双胍 黄连素 益生菌 腹泻 

分 类 号：R587.1[医药卫生—内分泌]