观察胸腔内注射尿激酶联合中心静脉导管引流治疗结核性胸腔积液的临床效果  

Clinical effect observation of intrapleural injection of urokinase combined with central venous catheter drainage in the treatment of tuberculous pleural effusion

作　　者：刘妮娜 邹家柳 LIU Ni-na;ZOU Jia-liu(Second Department of Internal Medicine,Dongkeng Hospital of Dongguan City,Dongguan 521450,China)

机构地区：[1]东莞市东坑医院内二科,521450

出　　处：《中国现代药物应用》2018年第19期19-21,共3页Chinese Journal of Modern Drug Application

基　　金：2017年东莞市社会科技发展(一般)项目申报书(项目编号:201750715037168)

摘　　要：目的研究胸腔内注射尿激酶联合中心静脉导管引流治疗结核性胸腔积液的临床效果。方法 60例结核性胸腔积液患者,按照治疗方法不同分为观察组和对照组,各30例。观察组接受胸腔内注射尿激酶联合中心静脉导管引流治疗,对照组接受常规胸腔穿刺抽液治疗。比较两组患者的临床效果。结果观察组患者积液消失时间、引流管留置时间、住院时间均短于对照组,总引流量多于对照组,胸膜厚度小于对照组,差异具有统计学意义(P<0.05)。观察组并发症发生率为10.00%,对照组并发症发生率为40.00%,比较差异具有统计学意义(P<0.05)。结论胸腔内注射尿激酶联合中心静脉导管引流治疗结核性胸腔积液能够提升临床治疗效果,且不会影响治疗安全性,可在临床推广。Objective To research the clinical efficacy of intrapleural injection of urokinase combined with central venous catheter drainage in the treatment of tuberculous pleural effusion. Methods A total of 60 patients with tuberculous pleural effusion were divided into observation group and control group, 30 cases in each group. The observation group was treated with intrapleural injection of urokinase combined with central venous catheter drainage, the control group was treated with conventional chest puncture extraction. The clinical efficacy of the two groups were compared. Results The disappearance time of effusion, indwelling time of drainage tube and length of stay in the observation group were significantly shorter than those in the control group, the total drainage volume of the observation group was significantly more than that of the control group, the pleural thickness of the observation group was significantly less than that of the contol group, the differences were statistically significant（P〈0.05）. The incidence of complications in the observation group was 10.00%, and that in the control group was 40.00%, the difference was statistically significant（P〈0.05）. Conclusion Intrathoracic injection of urokinase combined with central venous catheter drainage in the treatment of tuberculous pleural effusion can improve the clinical efficacy, and will not affect the safety of treatment, can be promoted in clinical practice.

关 键 词：胸腔内注射尿激酶 中心静脉导管引流 结核性胸腔积液 

分 类 号：R521.7[医药卫生—内科学]