CD4^+T细胞的分化调节及其在再生障碍性贫血中作用的研究进展  

The research development of CD4^+T cells and their molecular regulatory mechanism in aplastic anemia

作　　者：张珊 宋新龙 王爱迪[1] 谢东杰[1] 张乐[1] 刘宝山[1] ZHANG Shan;SONG Xin-long;WANG Ai-di;XIE Dong-jie;ZHANG Le;LIU Bao-shan(Department of Traditional Chinese Medicine,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院中医科,300052

出　　处：《天津医药》2018年第10期1123-1126,共4页Tianjin Medical Journal

基　　金：国家自然科学基金重点项目(81774062;81173415);天津医科大学"十三五"综合投资学科建设项目(11601501-2017xk0301)

摘　　要：CD4^+T细胞接受抗原的刺激后能够分化为多种辅助性T细胞(Th细胞)和调节性T细胞(Treg),是人体免疫系统重要的组成部分。随着对再生障碍性贫血和CD4^+T细胞研究的不断深入,发现CD4^+T细胞各亚群平衡失衡、功能亢进及细胞因子的异常活化造成的骨髓损伤是诱导再生障碍性贫血发病的重要原因。因此,研究CD4^+T细胞各个亚群的细胞分化调节,分析CD4+T细胞在再生障碍性贫血中的作用机制,可为再生障碍性贫血患者细胞亚群平衡的恢复提供治疗思路。本文拟从CD4^+T细胞、相关细胞因子等方面阐述CD4^+T细胞免疫异常对再障机制及治疗的影响。CD4＋ T cells can differentiate into a variely of auxiliaty T cells （Th cells） and regulatory T cells （Treg） after the stimulation of antigen, which is an important part of human immune system. With the further study of aplastic anemia and CD4＋ T cells, it is found that the imbalance of CD4＋ T cell subsets, hyperfunction and bone marrow injury caused by abnomlal activation of cytokines are important causes of the pathogenesis of aplastic anemia. Therefore, the study of cell differentiation and regulation of CD4＋ T cells and the analysis of the mechanism of CD4＋ T cells in aplastic anemia can provide therapeutic ideas for the recovery of cell subpopulation balance in patients with aplastic anemia. In this paper, the effects of CD4＋ T cell immune abnormalities on the mechanism and treatment of aplastic anemia were discussed from the aspects of CD4＋ T cells and related cytokines.

关 键 词：贫血 再生障碍性 综述 CD4+T细胞 TH1 TH2 TREG TH17 

分 类 号：R556.5[医药卫生—血液循环系统疾病]