自噬在人类免疫缺陷病毒和结核分枝杆菌共同感染中的作用  

Autophagy in human immunodeficiency virus and Mycobacterium tuberculosis coinfection

作　　者：张霞[1,2] 付玉荣[3] 李猛[1] 孟祥英[1] 高昆山 伊正君[1] Zhang Xia;Fu Yurong;Li Meng;Meng Xiangying;Gao Kunshan;Yi Zhengjun(Department of Laboratory Medicine;Department of Microbiology,Weifang Medical University,Shandong Province,Weifang 261053,China;Clinical Laboratory of Affliated Hospital of Weifang Medical University,Shandong Province,Weifang 261031,China)

机构地区：[1]山东省潍坊医学院医学检验学系,潍坊市261053 [2]山东省潍坊医学院附属医院检验科,潍坊市261031 [3]山东省潍坊医学院临床医学院微生物教研室,潍坊市261053

出　　处：《中华实验和临床感染病杂志（电子版）》2018年第4期313-315,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：山东省自然科学基金(No.ZR2016BL19)

摘　　要：人类免疫缺陷病毒/结核分枝杆菌(HIV/M.tb)共同感染已经成为发展中国家的主要公共卫生威胁。自噬是一种溶酶体分解代谢过程,正常状态下维持细胞内环境的稳态,还涉及细胞内病原体如HIV-1和M.tb的清除,可增强机体的免疫防御能力。本文概述在HIV-1和M.tb单独感染以及共同感染的背景下自噬对机体免疫防御的调控,全面了解病原体与自噬的相互作用,展望未来开发基于自噬原理新的预防性疫苗和治疗干预措施的巨大潜力。HIV/M.tb coinfection has become a major public health threat in developing countries. Autophagy is a process of lysosomal catabolism that maintains the homeostasis of the cell under normal conditions but also involves the clearance of intracellular pathogens such as HIV-1 and M.tb. It also enhances the host＇s immune defense mechanisms against infectious diseases. This review summarizes the regulation of autophagy on immune defense in the context of HIV-1 and M.tb infection alone and coinfection, overviews the comprehensive understanding of the pathogen-autophagy interaction and highlights the future development concerning the new prophylaxis vaccines improvement and the great potential of therapeutic interventions based on the principle of autophagy.

关 键 词：自噬 人类免疫缺陷病毒 结核分枝杆菌 共同感染 

分 类 号：R512.91[医药卫生—内科学]