EB病毒感染者162例临床分析  

Clinical analysis on 162 cases with Epstein-Barr virus infection

作　　者：潘婷 周培培 颜学兵 Pan Ting;Zhou Peipei;Yan Xuebing(Department of Infectoius Diseases,The Affliated Hospital of Xuzhou Medical University,Xuzhou 221002,China)

机构地区：[1]徐州医科大学附属医院感染性疾病科,徐州市221002

出　　处：《中华实验和临床感染病杂志（电子版）》2018年第4期348-353,共6页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

基　　金：国家自然科学基金(No.81371867);江苏省医学科技专项-新型临床诊疗技术攻关(No.BL2014033);江苏省"科教兴卫"医学重点人才培养基金(No.RC2011117);江苏省"六大人才高峰"项目(No.2011-WS-068)

摘　　要：目的探讨未成年与成人EB病毒(EBV)感染后的临床症状、体征、实验室指标差异,为临床诊断以及治疗提供依据。方法回顾性分析徐州医科大学附属医院于2017年6月至7月收治的162例EBV感染病例的一般资料、主要临床表现、实验室检查结果,包括发热、肝功能、血常规和EBV DNA载量等。根据年龄分为未成年组(113例)和成人组(49例)。结果两组患者首诊发热时间均以1周内为主(分别为80.8%和50%),差异具有统计学意义(Z=-2.504,P=0.012);发热热峰分别以中等度热(59.3%)与高热(55%)为主,差异无统计学意义(Z=-1.646,P=0.100)。两组患者白细胞计数(WBC)、中性粒细胞百分比(NE%)、淋巴细胞百分比(LY%)、淋巴细胞计数(LY)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBil)差异无统计学意义(P均>0.05),两组中性粒细胞计数(NE)(t=2.703、P=0.008)、谷氨酰转肽酶(GGT)(t=-3.370,P=0.001)和直接胆红素(DBil)(t=-2.068,P=0.043)水平差异均有统计学意义。未成年组患者EBV载量均值稍高于成人组,但差异无统计学意义(P> 0.05)。结论 EBV感染者均以发热、咽峡炎以及淋巴结肿大等为主要临床表现,检测EBV DNA有助于EBV感染的早期诊断与治疗,以减少相关疾病的发生。Objective To investigate the clinical symptoms, signs and laboratory examinations of minors and adult patients with Epstein-Barr virus（EBV） infection, and to provide a basis for clinical diagnosis and treatment. Methods The general data, main clinical manifestations and major laboratory indexes of 162 cases with EBV infection admitted to the Affiliated Hospital of Xuzhou Medical University from June to July 2017 were analyzed, retrospectively, including fever, liver function, blood routine examination, EBV DNA load and so on. All patients were divided into juvenile group（113 cases） and adult group（49 cases）. ResultsThe first diagnosis of fever was the highest in one week between juvenile group and adult group（80.8% and 50%, respectively）, the difference was significantly different（Z =-2.504, P = 0.012）. The moderate heat（59.3%） and the high fever（55%） were predominant for both groups of heat peaks, but there was no significant differences（Z =-1.646, P = 0.100）. There was no significant difference in white blood cell count（WBC）, neutrophile granulocyte percentage（NE%）, lymphocytes percentage（LY%）, lymphocyte count（LY）, alanine aminotransferase（ALT）, aspartate aminotransferase（AST） and total bilirubin（TBil） between the two groups（all〉 P 0.05）. The levels of while neutrophil counts（NE）（t = 2.703, P = 0.008）, glutamyl transpeptidase（GGT）（t =-3.370, P = 0.001） and direct bilirubin（DBil）（t =-2.068, P = 0.043） between the two groups were significantly different. The mean EBV load of cases in juvenile group was slightly higher than that of the adult group, but the difference was not significant（P〉 0.05）. Conclusions The main clinical manifestations of EBV infection are fever, pharyngitis and lymphadenopathy. The detection of EBV DNA contributes to the early diagnosis and treatment, and could reduce the occurrence of related diseases.

关 键 词：EB病毒 回顾性分析 EB病毒DNA 未成年人 成人 

分 类 号：R511[医药卫生—内科学]