血清甲状旁腺素检测在维持性血液透析患者中的应用  

The Application of Serum Levels of Parathyroid Hormone in the Maintenance Hemodialysis Patients

作　　者：赵敏[1] 杨贤芳[1] 戴宏华 ZHAO Min;YANG Xianfang;DAI Honghua(Department of Clinical Laboratory,Jurong City Hospital of Traditional Chinese Medicine,Jurong Jiangsu 212400,China)

机构地区：[1]句容市中医院检验科,江苏句容212400

出　　处：《中国继续医学教育》2018年第29期73-75,共3页China Continuing Medical Education

摘　　要：目的比较2种常用血液净化方法对维持性血液透析(MHD)患者血清甲状旁腺素(PTH)的清除效果;分析MHD患者PTH与超敏C反应蛋白(hs-CRP)水平之间的关系。方法选取本院维持性血液透析患者60例将其分为血液透析组(HD)和血液透析组+血液灌流(HD+HP)两组,分别测定治疗前后患者血清PTH及hs-CRP,并与健康人结果作比较。结果 HD+HP组患者治疗前后血清PTH水平分别为(352.38±109.88)pg/ml、(149.95±61.93)pg/ml,经统计学比较差异有统计学意义(P <0.01);而HD组患者治疗前后血PTH水平分别为(341.50±95.31)pg/ml、(298.95±82.56)pg/ml,治疗前后差异无统计学意义(P> 0.05)。MHD患者血清全段PTH平均水平为(357.52±103.67)pg/ml,较对照组(42.24±6.37)pg/ml显著升高(P<0.01),与血清hs-CRP呈正相关(r=0.432,P <0.05)。结论血液透析联合血液灌流与血液普通透析相比能更有效清除PTH,还应重视MHD患者联合检测PTH和hs-CRP的作用。Objective To determine the effects of different blood purifcation techniques on serum parathyroid hormone（PTH） and to analyze the relationship between levels of PTH and hypersensitiver C-reactive protein（hs-CRP）in patients with maintenance hemodialysis （MHD）. Methods Sixty maintenance hemodialysis patients with chronic renal failure were divided into hemodialysis hemoperfusion（HP＋HD）group and blood hemodialysis（HD） group. Before and after single treatment, serum levels of PTH and hs-CRP were measured, and the results were compared with those of healthy people. Results Serum levels of PTH in （HD＋HP） group decreased significantly from （352.38±109.88） pg/ml to （149.95±61.93） pg/ml after treatment, the difference was statistically significant （P 〈 0.01）, While serum PTH in HD group decreased from （341.50±95.31） pg/ml to （298.95±82.56） pg/ml, there was negative correlation between the two groups （P 〉 0.05）, The serum levels of intact PTH in MHD patients（357.52±103.67） pg/ml were signifcantly higher than those in the control people （42.24±6.37） pg/ml （P 〈 0.01）, The levels of intact PTH showed signifcantly positive correlations with the levels of CRP （r=0.432, P 〈 0.05）. Conclusion HD＋HP could efectively clear PTH, HD could not clear PTH, We would pay attention to the important role of PTH and hs-CRP in MHD patients.

关 键 词：血液透析 血液灌流 超敏C反应蛋白 甲状旁腺素 炎症 慢性肾功能衰竭 

分 类 号：R692[医药卫生—泌尿科学]