卡托普利对冠状动脉介入诊疗术后对比剂肾病(CIN)的预防作用分析  

Preventive Effect of Captopril on Contrast Induced Nephropathy(CIN) After Coronary Angiography

作　　者：杨亚 李民凤 YANG Ya;LI Minfeng(Cardiology Department,Chongqing People＇s Hospital,Chongqing 400010,China)

机构地区：[1]重庆市人民医院心血管内科,重庆400010

出　　处：《中国继续医学教育》2018年第29期145-146,共2页China Continuing Medical Education

摘　　要：目的探讨卡托普利对冠心病患者行冠状动脉造影术后对比剂肾病(CIN)的预防作用。方法选取到本院进行冠状动脉造影术的冠心病患者66例,随机分为使用观察组和对照组,每组33例,观察组采用卡托普利治疗,对照组未用卡托普利治疗,对比两组患者治疗后肾功能变化情况以及CIN发生率。结果观察组患者术后肾功能各项指标均优于对照组患者,组间对比差异有统计学意义(P <0.05)。对照组患者有8例发生CIN,CIN发生率为12.12%,观察组患者有1例发生CIN,CIN发生率为1.52%,观察组患者发生率低于对照组,组间对比差异有统计学意义(P <0.05)。结论冠心病患者行冠状动脉造影,术前应用卡托普利是安全的。Objective To explore the preventive effect of captopril on contrast induced nephropathy （CIN） after coronary angiography in patients with coronary heart disease. Methods 66 patients with coronary artery coronary artery angiography were randomly divided into the observation group and the control group, with 33 cases in each group. The observation group was treated with captopril, and the control group was not treated with captopril, and the basic data of the patients were recorded. Results The indexes of renal function in the observation group were better than those in the control group after operation, and the diference was statistically signifcant （P 〈 0.05）. The control group had 8 cases of CIN, the incidence of CIN was 12.12%. In the observation group, 1 patients developed CIN, the incidence of CIN was 1.52%. The incidence of patients in the observation group was lower than that in the control group, and the diference between the two groups was statistically signifcant （P 〈 0.05）. Conclusion It is safe to use captopril before coronary arteriography in patients with coronary heart disease.

关 键 词：卡托普利 冠心病 冠状动脉造影 对比剂肾病 肾功能 作用分析 

分 类 号：R541[医药卫生—心血管疾病]