Spontaneous activity in medial orbitofrontal cortex correlates with trait anxiety in healthy male adults  

成年男性特质型焦虑与内侧眶额的自发活动有关（英文）

作　　者：Shao-wei XUE Tien-wen LEE Yong-hu GUO 

机构地区：[1]Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, China [2]Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou 311121, China [3]Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, China [4]Department of Psychiatry, Dajia Lee's General Hospital, Lee "s Medical Corporation, Taichung 43 748, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2018年第8期643-653,共11页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the Natural Science Foundation of Zhejiang Province(No.LY17H180007);the Scientific Research Fund of Zhejiang Education Department(No.Y201431735);the Hangzhou Science and Technology Commission Foundation(No.20170533B06),China

摘　　要：Medial orbitofrontal cortex （mOFC） abnormalities have been observed in various anxiety disorders. However, the relationship between mOFC activity and anxiety among the healthy population has not been fully examined. Here, we conducted a resting state functional magnetic resonance imaging （R-fMRI） study with 56 healthy male adults from the Nathan Kline Institute/Rockland Sample （NKI-RS） to examine the relationship between the fractional amplitude of low-frequency fluctuation （fALFF） signals and trait anxiety across the whole brain. A Louvain method for module detection based on graph theory was further employed in the automated functional subdivision to explore subregional correlates of trait anxiety. The results showed that trait anxiety was related to fALFF in the mOFC. Additionally, the resting-state functional connectivity （RSFC） between the right subregions of the mOFC and the precuneus was correlated with trait anxiety. These findings provided evidence about the involvement of the mOFC in anxiety processing among the healthy population.目的:研究内侧眶额与焦虑加工的关系。创新点:采用Louvain网络模块检测方法对大脑内侧眶额进行自动化功能亚区分割,并发现内侧眶额与健康成年男性特质型焦虑的关系。方法:采用静息态低频振幅比率(fALFF)、静息态功能连通性(RSFC)和脑区功能亚区自动化分割方法。结论:成年男性特质型焦虑分数与内侧眶额的fALFF指标间存在显著相关性,并与右脑内侧眶额和楔前叶之间的功能连通性有关。因此,可以认为内侧眶额涉及特质型焦虑加工。

关 键 词：Trait anxiety Fractional amplitude of low-frequency fluctuation （fALFF） Medial orbitofrontal cortex PRECUNEUS Functional connectivity 

分 类 号：B845[哲学宗教—心理学]