复合丙泊酚时羟考酮抑制成年女性患者喉罩置入反应的半数有效剂量  

Median effective dose of oxycodone inhibiting responses to laryngeal mask airway insertion whencombined with propofol in adult female patients

作　　者：罗颖 于洋[2] 周小莲 俞正伟 赵红梅 孙建良 Luo Ying, Yu Yang, Zhou Xiaolian, Yu Zhengwei, Zhao Hongmei, Sun Jianliang,(1Department of Anesthesiology, Affiliated Hangzhou First People＇s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China ; 2Department of Anesthesiology, Beijing Aerospace General Hospital, Beijing 100076, China)

机构地区：[1]浙江大学医学院附属杭州市第一人民医院麻醉科,310006 [2]北京航天总医院麻醉科,100076

出　　处：《中华麻醉学杂志》2018年第5期562-564,共3页Chinese Journal of Anesthesiology

摘　　要：目的确定复合丙泊酚时羟考酮抑制成年女性患者喉罩置入反应的半数有效剂量（ED50）。方法择期行妇科手术患者，年龄18，60岁，体重指数18～24kg／m2，ASA分级I或Ⅱ级。采用序贯法进行试验。靶控输注丙泊酚行麻醉诱导．血浆靶浓度设定为3．0μg／ml。血浆靶浓度与效应室靶浓度达平衡时静脉注射羟考酮，初始剂量为0．11mg／kg，注射完毕5min时置入喉罩，发生喉罩置入反应时．下一例患者升高1个剂量梯度；否则降低1个剂量梯度。相邻剂量差值为0．02mg／kg。发生喉罩置入反应的标准：喉罩置入时发生吞咽、牙咬喉罩、呛咳和／或体动反应。采用Prob—it法计算复合丙泊酚时羟考酮抑制喉罩置入反应的ED。及其95％可信区间。结果复合丙}自酚时羟考酮抑制成年女性患者喉罩置入反应的ED50及其95％可信区间为0．095（0．080—0．108）mg／kg。结论复合丙泊酚时羟考酮抑制成年女性患者喉罩置入反应的ED50为0．095mg／kg。Objective To determine the median effective dose （ED50） of oxycodone inhibiting responses to laryngeal mask airway （ LMA ） insertion when combined with propofol in the adult female patients. Methods Female patients, aged 18-60 yr, with body mass index of 18-24 kg/m2, of American Society of Anesthesiologists physical status I or II , scheduled for elective gynecologic surgery, were included. EDso of oxycodone was determined by up-and-down sequential technique. Anesthesia was induced by target-controlled infusion of propofol at target plasma concentration of 3.0 txg/ml. Oxycodone was injected at the initial dose of 0. 11 mg/kg after the target effect-site and plasma concentratiOns were balanced. LMA was inserted at 5 rain following injection. When the response to LMA insertion was positive, the concentration of oxycodone was increased/decreased in the next patient. The difference between the two successive doses was 0. 02 mg/kg. LMA insertion response was defined as occurrence of swallowing, biting on the LMA and bucking and/or body movement during insertion. Probit analysis was used to calculate the EDs0 and 95% confidence interval of oxycodone inhibiting responses to LMA insertion when combined with propo- fbl. Results The ED50 （95% confidence interval） of oxycodone inhibiting responses to LMA insertion was 0. 095 （0. 080-0. 108） mg/kg when combined with propofol. Conclusion The EDs0 of oxycodone inhibiting responses to LMA insertion is 0. 095 mglkg when combined with propofol in the adult female patients.

关 键 词：羟可酮 喉面罩 剂量效应关系 药物 二异丙酚 成年人 女(雌)性 

分 类 号：R614[医药卫生—麻醉学]