上海地区化妆品所致接触性皮炎的致病成分分析  

Cosmetic ingredients that cause contact dermatitis in Shanghai

作　　者：秦鸥 王学民 谈益妹 胡蔚毅 程英 QIN Ou;WANG Xue-min;TAN Yi-mei;HU Wei-yi;CHENG Ying(Shanghai Dermatology Hospital,Shanghai 200443,China)

机构地区：[1]上海市皮肤病医院皮肤与化妆品研究室,上海200443

出　　处：《临床皮肤科杂志》2018年第10期625-627,共3页Journal of Clinical Dermatology

摘　　要：目的 :明确上海地区化妆品不良反应的主要致病成分,为化妆品不良反应起到预警作用并提供客观的风险评估依据。方法:于2013—2015年在上海使用化妆品变应原C-1000系列对343例调查对象进行斑贴试验,包括125例化妆品皮肤病患者和218例化妆品消费者。结果:阳性率前5位的变应原分别为甲基异噻唑啉酮、硫柳汞、Cl+Me-异噻唑、虫胶和六氢-1,3,5,-三(2-羟乙基)三嗪。将化妆品变应原系列分为14个类别,阳性率前5位的类别分别为着色剂、防腐剂、芳香剂、表面活性剂和杀菌剂。≤45岁人群的变应原阳性率显著高于>45岁人群。结论:上海地区最易引起化妆品皮肤病的变应原分别为甲基异噻唑啉酮、硫柳汞、Cl+Me-异噻唑、虫胶和六氢-1,3,5,-三(2-羟乙基)三嗪。≤45岁人群为化妆品皮肤病的高危发病人群,应避免接触化妆品变应原。Objective： To identify cosmetic ingredients causing adverse reactions in Shanghai, in order to make awareness of adverse reactions to cosmetics and provide basis for objective risk assessment of cosmetics. Methods： A total of 343 subjects, including 125 outpatients with cosmetic dermatosis and 218 normal cosmetic users, were patch-tested with the cosmetic series C-1000 in Shanghai from 2013 to 2015. Results： The top five leading allergens were methylisothiazolinone, thimerosal, methylisothiazolinone ＋methylchloro-isothiazolinone, shellac and hexahydro-l,3,5-tris-（2-hydroxyethyl）triazine. In 14 categories of C-1000 cosmetic series, the top five leading categories were colorant, preservative, fragrance mix, surfactant and bacteri- cide. The positive adverse reaction rate in subjects~≤45yrs old was significant higher than that in subjects〉45yrs old. Con- clusions： Methylisothiazolinone, thimerosal, methylisothiazolinone ＋methylchloro-isothiazolinone, shellac and hexahydro-l,3,5- tris-（2-hydroxyethyl）triazine are the most common cosmetic allergens causing cosmetic adverse reactions. Subjects≤45yrs old are at high risk of cosmetic dermatosis, and should avoid cosmetic allergens.

关 键 词：化妆品不良反应 化妆品皮肤病 斑贴试验 化妆品系列变应原 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]