2种维持量枸橼酸咖啡因治疗早产儿呼吸暂停的研究  

Clinical Study of the Two Maintenance Doses of Caffeine Citrate for Primary Apnea in Premature Infants

作　　者：应玲静 赵雨芳[1] 王叶萍[1] YING Lingjing;ZHAO Yufang;WANG Yeping(Jinhua Central Hospital,Zhejiang 321000,China)

机构地区：[1]金华市中心医院,浙江金华321000

出　　处：《浙江医学教育》2018年第5期43-45,57,共4页Zhejiang Medical Education

摘　　要：目的:观察2种维持量枸橼酸咖啡因治疗早产儿原发性呼吸暂停的临床疗效。方法:选取2015年6月至2017年6月本院住院的原发性呼吸暂停早产儿作为研究对象,随机分组,观察组枸橼酸咖啡因负荷量20 mg/kg*d,24h后改用维持量10mg/kg*d;对照组负荷量20 mg/kg*d,24h后改用维持量5mg/kg*d。对比2组的治疗疗效、不良反应及临床结局。结果:观察组治疗有效率、撤机成功率(82. 7%,88. 5%)高于对照组(60. 9%,71. 7%),P<0. 05;观察组的呼吸暂停症状消失时间(58. 02±13. 79) h短于对照组(77. 80±17. 02) h,P <0. 05。而不良反应和临床结局差异无统计学意义,P> 0. 05。结论:枸橼酸咖啡因维持量10mg/kg*d比5mg/kg*d更有利于提高早产儿呼吸暂停的临床疗效,而不增加不良反应。[Objective]To evaluate the effectiveness of the two maintenance doses of caffeine citrate treatment of primary apnea in premature infants. [Method]The premature infants presented w ith primary apnea,w ere recruited in our hospital from June 2015 to June 2017. They w ere randomly divided into tw o groups and w ere treated w ith caffeine citrate. The observation group took a loading dose of 20 mg/kg＊ d,maintenance dose of 10 mg/kg＊ d after 24 h; w hile the control group took a loading dose of 20 mg/kg＊ d,maintenance dose of 5 mg/kg＊ d after 24 h. The treatment effects,the occurrence of adverse reactions and clinical outcomes of patients in the tw o groups w ere compared. [Result]The effective rate of caffeine treatment and the success rate of w ithdraw ing respirator w ere higher in the observation group（ 82. 7%,88. 5%） compared w ith the control group（ 60. 9%,71. 7%）,P〈0. 05. The disappearance time of apnea w as low er in the observation group（ 58. 02 ± 13. 79 h） compared w ith the control group（ 77. 80 ± 17. 02 h）,P〈0. 05. No significant differences w ere observed concerning the incidence of caffeine-associated side effects and the clinical outcomes,P〈0.05. [Conclusion] Compared w ith the maintenance dose of caffeine citrate of 5 mg/kg＊ d,10 mg/kg＊ d can better improve the efficacy of the treatment effects,and w ill not cause more adverse events.

关 键 词：早产儿 原发性呼吸暂停 枸橼酸咖啡因 

分 类 号：R725.6[医药卫生—儿科]