肠道微生物与宿主免疫关系研究进展  

Research progress on the immunological relationship between intestinal microorganism and host

作　　者：金磊 王立志[1] Jin Lei;Wang Lizhi(Animal Nutrition Institute,Sichuan Agricultural University,Sichuan Chengdu 611130)

机构地区：[1]四川农业大学动物营养研究所,四川成都611130

出　　处：《现代畜牧兽医》2018年第9期52-58,共7页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：国家重点研发计划项目(2017YFD0502005);四川省肉牛创新团队(035Z2040)

摘　　要：动物胃肠道栖息着大量的微生物,这些微生物是与宿主长期共同进化的结果,参与机体代谢、营养和免疫等重要生理过程,尤其是免疫系统的发育和成熟。近年来研究发现肠道微生物与免疫系统间存在密切的交流和互作机制,它对MUC2蛋白和抗菌蛋白RegⅢγ的分泌以及免疫球蛋白(IgA)和调节性T细胞的诱导分化起重要作用。同时,大量的研究证明调控肠道微生物是一种高效治疗和控制肠道疾病的方法,如果这些机制能被人们清晰的认识,就可以通过调控宿主肠道微生物来达到预防和治疗疾病的目的。因此,本文综述了肠道微生物菌群与宿主免疫功能之间的关系。Abstract： The gastrointestinal tract of animals is inhabited by a large number of microbes. Intestinal microbes are the result of long-term co-evolution between the host and the microorgan - ism, and participate in the important physiological processes such as metabolism, nutrition and iMmunity, especially the development and maturation of the immune system. In recent years, a close communication and interaction mechanism between intestinal microorganism and immune system has been found. It plays an important role in the secretion of MUC2 protein and RegIIIγ gamma,as well as IgA and regulatory T cells. At the same time, a large number of studies have shown that the regulation of intestinal microbes is a highly effective method for the treatment and control of intestinal diseases. If these mechanisms can be clearly understood, the host intesti-nal microorganism can be regulated to prevent and treat the disease. Therefore, the relationship between intestinal Microorganism and host intestinal i^nune function is reviewed.

关 键 词：肠道 微生物 免疫 

分 类 号：S852.61[农业科学—基础兽医学]