精子鞭毛形态与精子运动参数的关系  

Relationship between sperm tail morphology and sperm motility parameters

作　　者：王改改 王家雄[1] 沈丽燕[1] 韩慕天 程洪波[1] 李红[1] 杨慎敏[1] WANG Gaigai;WANG Jiaxiong;SHEN Liyan;HAN Mutian;CHENG Hongbo;LI Hong;YANG Shenmin(Reproductive and Genetic Center,the Affiliated Suzhou Hospital of Nanjing Medical University,Suzhou Municipal Hospital,Jiangsu Province,Suzhou 215002,China)

机构地区：[1]南京医科大学附属苏州医院,苏州市立医院生殖与遗传中心,江苏苏州215002

出　　处：《中国医药导报》2018年第27期12-16,182,共6页China Medical Herald

基　　金：江苏省苏州市男性生殖研究重点实验室(SZS201718);江苏省苏州市“科教兴卫”青年科技项目(KJXW2017028)

摘　　要：目的探讨精子鞭毛形态与精子运动参数的关系。方法选取2015年11月～2017年12月苏州市立医院本部生殖遗传中心15 398例精液样本的检测结果 ,将样本分为弱精子症组(4941例)和精子活动率正常组(10 457例),统计两组精子的形态差异,分析精子鞭毛形态异常与精子运动参数的关系。结果两组精子形态畸形率差异有统计学意义(P<0.05),弱精子症组和正常组的颈部和中段成角弯曲[(9.41±3.62)%vs.(8.33±3.12)%]、短尾[(1.34±2.87)%vs.(0.74±1.08)%]、发夹样弯曲[(0.69±0.92)%vs.(0.64±0.81)%]、卷曲[(8.83±4.09)%vs.(7.53±3.52)%]、主段成角弯曲[(8.24±2.93)%vs.(7.65±2.58)%]比较,差异有统计学意义(P<0.05)。精子鞭毛畸形最常见的三种类型是中段成角弯曲、卷曲以及主段成角弯曲;随着这3种畸形所占比例的逐渐升高精子活动性逐渐降低,差异均有高度统计学意义(P<0.01)。结论精子鞭毛形态异常对精子运动参数有明显影响,对于弱精子症患者有必要观察其精子鞭毛形态。Objective To analyze the relationship between sperm tail morphology and sperm motility parameters.Methods A total of 15 398 specimens were collected from Reproductive and Genetic Center in Suzhou Municipal Hospital from November 2015 to December 2017. The samples were divided into asthenospermia group（4941 cases） and normal spermatozoa activity group（10 457 cases）. The morphological malformation statistics of the two groups were collected. The relationship of sperm tail morphology and sperm motility parameters were analyzed. Results The abnormal morphology rates of asthenospermia group and normal group were significantly different（P〈0.05）. There was statistically difference between asthenospermia group and the normal in mid piece angular bend [（9.41 ±3.62）% vs.（8.33 ±3.12）% ], short [（1.34 ±2.87）% vs.（0.74 ±1.08）% ], hairpin-like bend [（0.69 ±0.92）% vs.（0.64 ±0.81）% ], curled [（8.83 ±4.09）% vs.（7.53±3.52）%], and main piece angular bend [（8.24±2.93）% vs.（7.65±2.58）%]（P〈0.05）. The most common types of abnormal sperm tail morphology were mid piece angular bend, curling and main piece angular bend. Sperm motility gradually decreased as the proportion of the three kinds of malformations gradually increased. With the increase of the proportion of these three deformities sperm motility gradually malcreased, the differences were highly statistically significant（P〈0.01）. Conclusion Sperm tail morphology malformation on sperm motility parameters has statistically influence. It is necessary to observe the sperm tail morphology of asthenospermia patients.

关 键 词：精子形态 精子活动率 鞭毛异常 男性不育 

分 类 号：R698.2[医药卫生—泌尿科学]